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Usage

Uses

Used in Pharmaceutical Industry:
5'-fluoro-2'-hydroxybutyrophenone is used as a potential therapeutic agent for [application reason] due to its structural similarity to droperidol, which has established uses as an antipsychotic and antiemetic medication. The presence of a fluorine atom and a hydroxyl group may confer additional pharmacological properties, making it a candidate for further exploration in drug development.
Used in Medicinal Chemistry Research:
5'-fluoro-2'-hydroxybutyrophenone serves as a subject of interest for researchers in medicinal chemistry, as its unique structure and potential biological activity may lead to the discovery of new therapeutic agents or provide insights into the mechanisms of action of existing drugs.
Used in Pharmacology Studies:
In pharmacology, 5'-fluoro-2'-hydroxybutyrophenone is used as a research tool to investigate the effects of structural modifications on the pharmacological profile of drugs. Its potential as a modulator of neurotransmission or other biological processes could be explored, contributing to a better understanding of drug action and the development of more effective treatments.

Upstream product

• 587-89-3 n-butyrate de fluoro-4 phenyl 
• 371-41-5 4-Fluorophenol 
• 107-92-6 butyric acid 
• 107-06-2 1,2-dichloro-ethane 

Downstream Products

• 16113-36-3 1-(4-Fluor-benzoylhydrazono)-1-(5-fluor-2-hydroxy-phenyl)-butan 
• 16167-62-7 1-<4-Fluor-benzolsulfonylhydrazono>-1-<5-fluor-2-hydroxy-phenyl>-butan 
• 16167-60-5 1-(4-Acetamino-benzolsulfonylhydrazono)-1-(5-fluor-2-hydroxy-phenyl)-butan 
• 1627503-04-1 2-ethyl-5-fluoro-2-morpholinobenzofuran-3(2H)-one 
• 1632055-84-5 2-ethyl-5-fluoro-2-(4-nitrophenoxy)benzofuran-3(2H)-one 

Relevant academic research and scientific papers

The insertion of arynes into the O-H bond of aliphatic carboxylic acids

The insertion of arynes into the O-H bond of aliphatic carboxylic acids promoted by sodium carboxylates is described. The reactions led to the formation of aryl carboxylates in good yields with good chemoselectivities under mild conditions.

Isolement et identification des impuretes formees au cours de la synthese industrielle de la fluoro-5 hydroxy-2 butyrophenone par transposition de Fries

P-fluorophenyl n-butyrate dissolved in 1,2-dichloro-ethane is rearranged via an Aluminium chloride catalysed Fries rearrangement at a temperature of 100 deg C.Together with expected compound (85percent) four other ketones have been isolated.Formation of these ketones can be explained by reaction of Aluminium chloride on 1,2-dichloroethane producing vinyl chloride.One of them, the 1-(5-fluoro-2-hydroxyphenyl)-trans-1-hexen-3-one stems from the p-fluorophenol produced by heterolytic cleavage of the ester.It is then alkylated in the ortho position of the hydroxyl group.Formation of the three other ketones proceeds through alkylation of the ester in the meta position prior to the Fries reaction.Therefore, these ketones have an alkyl radical in meta position of the hydroxyl group.The simplest of them is 4'-ethyl-5'-fluoro-2'-hydroxy-butyrophenone.The two others are diketones, belonging to 1,1-diphenylethane series.An ethylidene bridge is created between the two aromatic rings.Total yield of identified compounds exceeds 96percent.No fluorine elimination has been noticed.Involvement of 1,2-dichloroethane in the Fries reaction is therefore confirmed.