57506-52-2

Upstream product

• 487-89-8 Indole-3-carboxaldehyde 
• 86427-24-9 3-(N-p-tolylethyliminomethyl)indole 
• 100-46-9 benzylamine 
• 120-72-9 indole 

Downstream Products

• 57506-64-6 N-(1H-indol-3-ylmethyl)-N-benzylamine 
• 86427-38-5 3-(1-benzyl-3-chloro-2-oxo-azetidinyl)indole 
• 1151843-60-5 C₁₉H₂₀N₂ 
• 879375-61-8 carbonic acid 4-[benzyl-(1H-indol-3-ylmethyl)-amino]-but-2-enyl ester methyl ester 
• 879375-43-6 4-[benzyl-(1H-indol-3-ylmethyl)-amino]-but-2-enoic acid ethyl ester 
• 879375-51-6 4-[benzyl-(1H-indol-3-ylmethyl)-amino]-but-2-en-1-ol 

Relevant academic research and scientific papers

Streptochlorin analogues as potential antifungal agents: Design, synthesis, antifungal activity and molecular docking study

Streptochlorin is a small molecule of indole alkaloid isolated from marine Streptomyces sp., it is a promising lead compound due to its potent bioactivity in preventing many phytopathogens in our previous study, but further structural modifications are re

Sequential one-pot cyclizations: Concise access to the ABCE tetracyclic framework of strychnos alkaloids

A sequential one-pot biscyclization route to the ABCE tetracyclic framework of Strychnos alkaloids has been developed. Specifically, the AgOTf-mediated spirocyclization of an appropriately functionalized indole 3-carbinamide afforded a stable spiroindolen

Allosteric functional switch of neurokinin A-mediated signaling at the neurokinin NK2 receptor: Structural exploration

The neurokinin NK2 receptor is known to pre-exist in equilibrium between at least three states: restinginactive, calcium-triggering, and cAMP-producing. Its endogeneous ligand, NKA, mainly induces the calcium response. Using a FRET-based assay, we have previously discovered an allosteric modulator of the NK2 receptor that has the unique ability to discriminate among the two signaling pathways: calcium-signaling is not affected while cAMP signaling is significantly decreased. A series of compounds have been prepared and studied in order to better understand the structural determinants of this allosteric functional switch of a GPCR. Most of them display the same allosteric profile, with smooth pharmacomodulation. One compound however exhibits significantly improved modulatory properties of NKA induced signaling when compared to the original modulator. 2009 American Chemical Society.

Highly enantioselective synthesis of tetrahydro-β-carbolines and tetrahydro-γ-carbolines via Pd-catalyzed intramolecular allylic alkylation

A novel Pd-catalyzed intramolecular allylic alkylation of indoles allows THBCs and THGCs to be effectively synthesized in high yields and excellent enantiomeric excesses (ee up to 97%). Copyright

Indole derivatives with antimycobacterial activity

1,3-Dinitro-2-(indol-3'-yl)-propanes 3 are synthesized by Michael reaction of nitromethane with the indolylnitroethenes 2. - Reaction of the aldehydes 4 and 10 with the benzylamines 12 as well as the reaction of the indolylalkylamines 6a and 9a with the benzaldehydes 11 lead to Schiff bases which are reduced to N-benzyl-(indol-3-ylmethyl)-amines 13 and N-benzyl-(indol-3-ylethyl)-amines 14, respectively; tert amines 16 are synthesized via the formamides 15, amines 18 are prepared according to Mannich. - Inhibitory effects on Mycobacterium tuberculosis H 37 Ra are investigated, a structure-activity relationship is discussed.

Substituted Azitidinonylindoles and Thiazolidinonylindoles as Antiparkinsonian Agents

3-(1-Arylalkyl-3-chloro-2-oxo-4azetidinyl)indoles (IIa-h) and 3-(3-arylalkyl-4-oxo-2-thiazolinyl)indoles (IIi-n) have been synthesized by the cyclocondensation of 3-(N-arylalkyliminomethyl)indoles (Ia-h) with chloroacetyl and thioglycolic acid respectivel