5751-52-0

Basic information

• Product Name: 7-METHOXY-4H-CHROMEN-4-ONE
• Synonyms: 7-METHOXY-4H-CHROMEN-4-ONE;4H-1-Benzopyran-4-one, 7-Methoxy-;7-Methoxy-chromen-4-one
• CAS NO: 5751-52-0
• Molecular Formula: C₁₀H₈O₃
• Molecular Weight: 176.17
• Mol File: 5751-52-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 56-57 °C
• Boiling Point: 305.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.248±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 7-METHOXY-4H-CHROMEN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHOXY-4H-CHROMEN-4-ONE(5751-52-0)
• EPA Substance Registry System: 7-METHOXY-4H-CHROMEN-4-ONE(5751-52-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 5751-52-0(Hazardous Substances Data)

Usage

General Description

7-Methoxy-4H-chromen-4-one is a chemical compound with the molecular formula C10H8O3 and a molecular weight of 176.17 g/mol. It is a derivative of the natural compound coumarin and is commonly used as a synthon in organic synthesis. 7-METHOXY-4H-CHROMEN-4-ONE exhibits various biological activities, including anti-inflammatory, antioxidant, and anti-tumor properties. It has also been studied for its potential use as an anticoagulant and for the treatment of vascular diseases. 7-Methoxy-4H-chromen-4-one is a yellow crystalline solid at room temperature and is soluble in organic solvents such as ethanol and acetone. Its diverse biological activities make it an important target for pharmaceutical and medicinal chemistry research.

Upstream product

• 73220-33-4 (2E)-3-(dimethylamino)-1-(2-hydroxy-4-methoxyphenyl)-2-propen-1-one 
• 62437-99-4 2-hydrazinylpyridine dihydrochloride 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 

Downstream Products

• 57052-72-9 2,3-Dihydro-7-hydroxy-4H-1-benzopyran 
• 151254-88-5 8-amino-7-<(6-phenylhexyl)oxy>-4-chromanone 
• 151254-87-4 8-amino-7-<4-<(4-methoxyphenyl)oxy>butoxy>-4-chromanone 
• 151254-90-9 4-hydroxy-N-(7-methoxy-4-oxochroman-8-yl)benzamide 
• 1412410-80-0 (E)-N-(4-fluorophenethyl)-3-(7-methoxy-4-oxo-4H-chromen-3-yl) acrylamide 
• 1412410-79-7 (E)-N-benzyl-3-(7-methoxy-4-oxo-4H-chromen-3-yl)acrylamide 
• 1412410-78-6 (E)-N-(4-fluorophenyl)-3-(7-methoxy-4-oxo-4H-chromen-3-yl)acrylamide 
• 1412410-77-5 (E)-3-(7-methoxy-4-oxo-4H-chromen-3-yl)-N-(4-methoxyphenyl)acrylamide 
• 1412410-76-4 (E)-3-(7-Methoxy-4-oxo-4H-chromen-3-yl)-N-phenylacrylamide 
• 1160309-64-7 (E)-7-methoxy-3-(3-nitrostyryl)-4H-chromen-4-one 
• 1160309-60-3 (E)-7-methoxy-3-(4-nitrostyryl)-4H-chromen-4-one 
• 1412410-75-3 (E)-3-(3-fluorostyryl)-7-methoxy-4H-chromen-4-one 
• 1160309-57-8 (E)-3-(4-ethoxystyryl)-7-methoxy-4H-chromen-4-one 

Relevant articles and documents

Synthesis and biological evaluation of novel pyrazole derivatives with anticancer activity

We synthesized thirty-six novel pyrazole derivatives and studied their antiproliferative activity in human ovarian adenocarcinoma A2780 cells, human lung carcinoma A549 cells, and murine P388 leukemia cells. Four of these substances were selected because of their higher antiproliferative activity and further analyses showed that they were all able to induce apoptosis, although to a different extent. The expression of p53 and p21waf1, which induce apoptosis and cell cycle arrest, was evaluated by western blot analysis in cells treated with compound 12d. The analysis of the cell cycle showed that all the selected compounds cause a partial G2/M block and the formation of polyploid cells. Furthermore, the four selected compounds were tested for their interaction with the microtubular cytoskeletal system by docking analysis, tubulin polymerization assay and immunofluorescence staining, demonstrating that the compound 12d, unlike the other active derivatives, was able to significantly bind dimers of α- and β-tubulin, probably causing a molecular distortion resulting in the disassembly of microtubules.