5751-52-0

Basic information

• Product Name: 7-METHOXY-4H-CHROMEN-4-ONE
• Synonyms: 7-METHOXY-4H-CHROMEN-4-ONE;4H-1-Benzopyran-4-one, 7-Methoxy-;7-Methoxy-chromen-4-one
• CAS NO: 5751-52-0
• Molecular Formula: C₁₀H₈O₃
• Molecular Weight: 176.17
• Mol File: 5751-52-0.mol

Chemical Properties

• Melting Point: 56-57 °C
• Boiling Point: 305.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.248±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 7-METHOXY-4H-CHROMEN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHOXY-4H-CHROMEN-4-ONE(5751-52-0)
• EPA Substance Registry System: 7-METHOXY-4H-CHROMEN-4-ONE(5751-52-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 5751-52-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Medicinal Chemistry Research:
7-Methoxy-4H-chromen-4-one is used as a research compound for its diverse biological activities, such as anti-inflammatory, antioxidant, and anti-tumor properties. Its potential applications in the development of new drugs and therapies are being explored.
Used in Organic Synthesis:
As a synthon, 7-Methoxy-4H-chromen-4-one is used in organic synthesis to create various chemical compounds. Its unique structure and reactivity make it a valuable building block for the synthesis of complex organic molecules.
Used in Anti-inflammatory Applications:
7-Methoxy-4H-chromen-4-one is used as an anti-inflammatory agent, potentially reducing inflammation and alleviating symptoms associated with inflammatory conditions.
Used in Antioxidant Applications:
7-METHOXY-4H-CHROMEN-4-ONE is used as an antioxidant, helping to neutralize free radicals and protect cells from oxidative damage, which may contribute to the prevention of various diseases and aging processes.
Used in Anti-tumor Applications:
7-Methoxy-4H-chromen-4-one is used as an anti-tumor agent, exhibiting potential anti-cancer properties and being studied for its ability to inhibit tumor growth and proliferation.
Used in Antithrombotic and Vascular Disease Treatment:
7-Methoxy-4H-chromen-4-one is being studied for its potential use as an anticoagulant and in the treatment of vascular diseases, due to its ability to affect blood clotting and improve blood flow.

Upstream product

• 73220-33-4 (2E)-3-(dimethylamino)-1-(2-hydroxy-4-methoxyphenyl)-2-propen-1-one 
• 62437-99-4 2-hydrazinylpyridine dihydrochloride 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 

Downstream Products

• 57052-72-9 2,3-Dihydro-7-hydroxy-4H-1-benzopyran 
• 59887-89-7 7-hydroxy-4H-chromen-4-one 
• 18385-69-8 7-methylchroman-4-one 
• 1388223-86-6 C₁₅H₁₉NO₃ 
• 1412410-82-2 (E)-3-(7-hydroxy-4-oxo-4H-chromen-3-yl)-N-phenylacrylamide 

Relevant articles and documents

Synthesis and biological evaluation of novel pyrazole derivatives with anticancer activity

We synthesized thirty-six novel pyrazole derivatives and studied their antiproliferative activity in human ovarian adenocarcinoma A2780 cells, human lung carcinoma A549 cells, and murine P388 leukemia cells. Four of these substances were selected because of their higher antiproliferative activity and further analyses showed that they were all able to induce apoptosis, although to a different extent. The expression of p53 and p21waf1, which induce apoptosis and cell cycle arrest, was evaluated by western blot analysis in cells treated with compound 12d. The analysis of the cell cycle showed that all the selected compounds cause a partial G2/M block and the formation of polyploid cells. Furthermore, the four selected compounds were tested for their interaction with the microtubular cytoskeletal system by docking analysis, tubulin polymerization assay and immunofluorescence staining, demonstrating that the compound 12d, unlike the other active derivatives, was able to significantly bind dimers of α- and β-tubulin, probably causing a molecular distortion resulting in the disassembly of microtubules.