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Usage

Uses

Used in Pharmaceutical Industry:
2,4-diamino-6-chloromethylpteridine is used as a chemical compound for its potential role in the development of pharmaceuticals. Its unique structure allows it to be a promising candidate for creating new drugs and therapies.
Used as a Reagent in Chemical Reactions:
In the field of chemistry, 2,4-diamino-6-chloromethylpteridine serves as a reagent that facilitates various chemical reactions. Its functional groups enable it to participate in a range of processes, making it a valuable tool for researchers and chemists.
Used in Biochemical Research:
2,4-diamino-6-chloromethylpteridine is also of interest in biochemistry, where it is being investigated for its role in different biological processes. Its presence in studies can help scientists better understand certain mechanisms and develop targeted treatments or interventions.

InChI:InChI=1/C7H7ClN6/c8-1-3-2-11-6-4(12-3)5(9)13-7(10)14-6/h2H,1H2,(H4,9,10,11,13,14)

Upstream product

• 945-24-4 2,4-diamino-6-(hydroxymethyl)pteridine 
• 14337-41-8 1-chloro-3-(hydroxyimino)acetone 
• 39944-62-2 2,4,5,6-tetraamino-pyrimidine dihydrochloride 

Relevant academic research and scientific papers

A new, general and regioselective method for the synthesis of 2,6-disubstituted 4-aminopteridines

A new synthetic method for the preparation of 2,6-disubstituted 4-aminopteridines is described. Treatment of a-substituted 4,5,6-triaminopyrimidines with α-ketoaldoximes in MeOH affords in a regioselective one-step reaction 2,6-disubstituted 4-aminopteridines in high yield.

Process of preparing N[p-{[(2,4-diamino-6-pteridyl)-methyl]N10 -methylamino}-benzoyl]-glutamic acid

A three-step process is provided for preparing the L,D and DL isomers of N[p-{[(2,4-diamino-6-pteridyl)-methyl]N10 -methylamino}-benzoyl]-glutamic acid. The first step produces: 2,4-diamino-6-hydroxymethyl pteridine by condensation in a buffered aqueous media of 2,3,4,5-tetraminopyrimidine dihydrochloride with the bisulphite addition product of 1,3-dihydroxyacetone in the presence of cysteine as catalyst and using selenium dioxide and a continuous air bubbling as oxidation agents. In the next step, 2,4-diamino-6-halomethylpteridine is obtained by halogenation of the previously obtained 2,4-diamino-6-hydroxymethylpteridine in an inert media with a halogenation agent such as thionyl chloride, in the presence of a basic catalyst such as pyridine or triethylamine. In the third step, N[p-{[(2,4-diamino-6-pteridyl)-methyl]-N10 -methylamino}-benzoyl-]-glutamic acid is produced by condensation of the 2,4-diamino-6-halomethylpteridine with N[p-(N-methylamino)-benzoyl]-glutamic acid at pH 3-4 in an aqueous buffered solution.