57532-84-0Relevant academic research and scientific papers
Copper-free Sandmeyer-type Reaction for the Synthesis of Sulfonyl Fluorides
Zhong, Tao,Pang, Meng-Ke,Chen, Zhi-Da,Zhang, Bin,Weng, Jiang,Lu, Gui
supporting information, p. 3072 - 3078 (2020/04/10)
A copper-free Sandmeyer-type fluorosulfonylation reaction is reported. Utilizing Na2S2O5 and Selectfluor as the sulfur dioxide and fluorine sources, respectively, aryldiazonium salts were transformed into sulfonyl fluorides. The one-pot direct synthesis of sulfonyl fluorides from aromatic amines was also realized via in situ diazotization. The practicality of this method was demonstrated by the broad functional group tolerance, gram-scale synthesis, and late-stage fluorosulfonylation of natural products and pharmaceuticals.
Process for preparation of aromatic sulfone compounds
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, (2008/06/13)
An aromatic hydrocarbon represented by the following general formula [I]: STR1 wherein R1, R2 and R3 stand for a hydrogen atom or alkyl group, is reacted with a halogenated sulfonic acid in the presence of a Lewis acid to obtain an aromatic sulfone compound represented by the following general formula [II]: STR2 wherein R1, R2 and R3 are as defined above and Z stands for a halogen atom or an aromatic hydrocarbon group represented by the following general formula [III]: STR3 in which R1, R2 and R3 are as defined above.
OXIDATION OF METHYL-SUBSTITUTED BENZENESULFONYL FLUORIDES IN THE PbO2-HSO3F SYSTEM
Arapov, O. V.,Rudenko, A. P.,Zarubin, M. Ya.
, p. 152 - 163 (2007/10/02)
The transformations of the sulfonyl fluorides of methyl-substituted benzenes in the PbO2-HSO3F system were studied.They take place through a stage involving the one-electron oxidation of the substrate to aromatic radical-cations.One of the transformation paths of the latter is realized through the elimination of a proton from the methyl groups involved to the greatest degree in the delocalization of the unpaired electron.This leads to the formation of diarylmethanes and the fluorosulfonates of substituted benzyl alcohols, which give substituted tolylsultones and benzyl alcohols during hydrolysis of the acid solution and methyl ethers of benzyl alcohols during methanolysis.The other path, which arises during localization of the unpaired electron in the unsubstituted positions of the benzene ring, leads to biaryls.
