575446-88-7Relevant academic research and scientific papers
Mild method for the conversion of amides to thioamides
Charette, Andre B.,Grenon, Michel
, p. 5792 - 5794 (2003)
Aqueous ammonium sulfide was found to be an ideal substitute for hydrogen sulfide for the thiolysis of activated amides. High yields of the corresponding thioamides were obtained for a broad range of substrates, using two different procedures that are both operationally simple and inexpensive, as well as amenable to large-scale preparation. Preliminary results indicate that aqueous ammonium sulfide may also replace hydrogen sulfide in the synthesis of thionoesters from amides.
