575455-32-2Relevant academic research and scientific papers
Synthesis of new pseudonucleosides containing chiral cyclosulfamides as agycone
Berredjem, Malika,Aouf, Nour-Eddine
, p. 671 - 673 (2003)
A series of chiral cyclosufamides have been synthesized in four steps, starting from N-benzoylaminoacids. Regioselective glycosylation of these pseudopyrimidic heterocycles was carried out after deprotection. Best glycosylation results were obtained by pr
New pseudonucleosides containing chiral oxazolidin-2-ones and Cyclosulfamides as aglycones: Synthesis and antiviral evaluation
Bouleghlem, Hocine,Berredjem, Malika,Lecouvey, Marc,Aouf, Nour-Eddine
, p. 1539 - 1542 (2008/09/20)
A series of chiral cyclosulfamides and oxazolidinon-2-ones have been synthesized starting from aminoacids. Regioselective substitution of these pseudopyrimidic heterocyles was carried out under Mitsunobu conditions. Best substitution results were obtained by preliminary deprotection of cyclosulfamides and their condensation with β -D-ribofuranose. Chiral oxazolidin-2-ones were coupled directly with D-ribofuranose. All compounds were tested against HSV-2, VV and SV viruses. Two compounds 6b and 6e showed significant activities against HSV-type 1. Copyright Taylor & Francis Group, LLC.
Simple and Efficient Cleavage Reaction of the Boc Group in Heterocyclic Compounds
Nadia, Klai,Malika, Berredjem,Nawel, Khettache,MedYazid, Belghit,Zine, Regainia,Aouf, Nour-Eddine
, p. 57 - 60 (2007/10/03)
A series of chiral cyclosulfamides have been synthesized by alkaline cyclisation starting from N-benzoylamino acids (Ala, Val, Leu, Phe) derivatives and chlorosulfonyl isocyanate. A simplified and regioselective deprotection of the cyclic compounds (cyclosulfamides) containing the tert-butyloxycarbonyl group (Boc) has been achieved in good yield by fusion under reduced pressure.
Regiospecific synthesis and N-acylation of chiral 1,2,5-thiadiazolidines 1,1-dioxides
Berredjem, Malika,Djebbar, Houria,Regainia, Zine,Aouf, Nour-Eddine,Dewynter, Georges,Winum, Jean-Yves,Montero, Jean-Louis
, p. 693 - 705 (2007/10/03)
The regiospecific synthesis of chiral N-acyl cyclosulfamides (sulfa-analogues of cyclic ureas) was carried out starting from chlorosulfonyl isocyanate (CSI), 1-substituted N-benzyl-2-chloroethylamine hydrochloride and acyl chloride. Chiral N-acyl-thiadiazolidines 1,1-dioxides have been prepared in high yield starting from the corresponding cyclosulfamides acyl chloride, triethylamine and a catalytic amount of 4-(N,N-dimethylamino)pyridine.
