575465-27-9Relevant academic research and scientific papers
Design, synthesis, and biological evaluation, of the first selective nonpeptide AT2 receptor agonist
Wan, Yiqian,Wallinder, Charlotta,Plouffe, Bianca,Beaudry, Hélène,Mahalingam,Wu, Xiongyu,Johansson, Berndt,Holm, Mathias,Botoros, Milad,Karlén, Anders,Pettersson, Anders,Nyberg, Fred,F?ndriks, Lars,Gallo-Payet, Nicole,Hallberg, Anders,Alterman, Mathias
, p. 5995 - 6008 (2007/10/03)
The first druglike selective angiotensin II AT2 receptor agonist (21) with a Ki value of 0.4 nM for the AT2 receptor and a Ki > 10 μM for the AT1 receptor is reported. Compound 21, with a bioavailability of 20-3
