575474-01-0

Usage

Uses

Used in Pharmaceutical Applications:
3,4-Dihydro-2H-1,4-benzoxazin-7-amine is used as an anti-cancer agent for its potential to target and inhibit the growth of cancer cells. Its mechanism of action is still under investigation, but it has shown promise in combating various types of cancer.
Used in Agricultural Applications:
In the agricultural industry, 3,4-dihydro-2H-1,4-benzoxazin-7-amine is used as a natural pesticide. It exhibits insecticidal and antimicrobial properties, making it a potential alternative to synthetic pesticides. Its ability to inhibit the growth of certain insects and pathogens could contribute to more sustainable and environmentally friendly crop protection strategies.
Further research is necessary to fully understand the potential applications and mechanisms of action of 3,4-dihydro-2H-1,4-benzoxazin-7-amine, as well as to explore its possible use in other industries and therapeutic areas.

Upstream product

• 26215-14-5 7-amino-2H-1,4-benzoxazin-3(4H)-one 
• 81721-86-0 7-nitro-4H-benzo[1,4]oxazin-3-one 
• 121-88-0 5-Nitro-2-aminophenol 

Downstream Products

• 59-31-4 2-quinolone 

Relevant academic research and scientific papers

PYRAZOLE DERIVATIVES FOR THE TREATMENT OF CYSTIC FIBROSIS

The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof. It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular to modulate CFTR protein or ABC protein activities.

Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides

The vanilloid receptor-1 (TRPV1 or VR1) is a member of the transient receptor potential (TRP) family of ion channels and plays a role in regulating the function of sensory nerves. A growing body of evidence demonstrates the therapeutic potential of TRPV1 modulators, particularly in the management of pain. As a result of our screening efforts, we identified (E)-3-(4-tert- butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (1), an antagonist that blocks the capsaicin-induced and pH-induced uptake of 45Ca2+ in TRPV1-expressing Chinese hamster ovary cells with IC50 values of 17 ± 5 and 150 ± 80 nM, respectively. In this report, we describe the synthesis and structure-activity relationship of a series of N-aryl cinnamides, the most potent of which (49a and 49b) exhibit good oral bioavailability in rats (Foral = 39% and 17%, respectively).