57556-49-7

Basic information

• Product Name: N1-(4-AMINO-2-CHLOROPHENYL)ACETAMIDE
• Synonyms: 4-AMINO-2-CHLORO ACETANILIDE;N-(4-AMINO-2-CHLOROPHENYL)ACETAMIDE;N1-(4-AMINO-2-CHLOROPHENYL)ACETAMIDE
• CAS NO: 57556-49-7
• Molecular Formula: C₈H₉ClN₂O
• Molecular Weight: 184.62
• Mol File: 57556-49-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 131-133°C
• Boiling Point: 294.9 °C at 760 mmHg
• Flash Point: 132.1 °C
• Appearance: /
• Density: 1.35 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N1-(4-AMINO-2-CHLOROPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N1-(4-AMINO-2-CHLOROPHENYL)ACETAMIDE(57556-49-7)
• EPA Substance Registry System: N1-(4-AMINO-2-CHLOROPHENYL)ACETAMIDE(57556-49-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 57556-49-7(Hazardous Substances Data)

Usage

Chemical Properties

Grey brown crystalline powder

Upstream product

• 881-87-8 N-(2-chloro-4-nitrophenyl)acetamide 
• 7803-57-8 hydrazine hydrate 
• 121-87-9 2-Chloro-4-nitroaniline 

Downstream Products

• 1432135-75-5 N-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4.3-b]pyridin-3-yl]amino}phenyl)acetamide 
• 1432112-28-1 2-chloro-N-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-4-fluorobenzamide 
• 1432112-27-0 2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-1H-pyrrolo[3,4-c] pyridine-1,3(2H)-dione 
• 1432112-24-7 2-chloro-N⁴-[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]benzene-1,4-diamine 
• 106472-14-4 N,N'-bis-(4-amino-3-chloro-phenyl)-urea 
• 105168-76-1 Piperidine-1-sulfonic acid (4-amino-3-chloro-phenyl)-amide 
• 105168-73-8 C₈H₁₂ClN₃O₂S 
• 87223-53-8 C₁₃H₁₅ClN₄O₅ 
• 105168-72-7 C₁₀H₁₄ClN₃O₃S 
• 105168-75-0 N-[2-Chloro-4-(piperidine-1-sulfonylamino)-phenyl]-acetamide 
• 101571-47-5 N,N'-bis-(4-acetylamino-3-chloro-phenyl)-urea 

Relevant articles and documents

Variable noninnocence of substituted azobis(phenylcyanamido)diruthenium complexes

The synthetic chemistry of substituted 4,4′-azobis(phenylcyanamide) ligands was investigated, and the complexes [{Ru(tpy)(bpy)}2( μ-L)][PF6]2, where L = 2,2′:5,5′-tetramethyl-4,4′-azobis(phenylcyanamido) (Me4adpc2-), 2,2′-dimethyl-4,4′-azobis(phenylcyanamido) (Me2adpc2-), unsubstituted (adpc2-), 3,3′-dichloro-4,4′-azobis(phenylcyanamido) (Cl2adpc2-), and 2,2′:5,5′-tetrachloro-4,4′-azobis(phenylcyanamido) (Cl4adpc2-), were prepared and characterized by cyclic voltammetry and vis-near-IR (NIR) and IR spectroelectrochemistry. The room temperature electron paramagnetic resonance spectrum of [{Ru(tpy)(bpy)}2( μ-Me4adpc)]3+ showed an organic radical signal and is consistent with an oxidation-state description [RuII, Me4adpc?-, RuII]3+, while that of [{Ru(tpy)(bpy)}2( μ-Cl2adpc)]3+ at 10 K showed a low-symmetry RuIII signal, which is consistent with the description [RuIII, Cl2adpc2-, RuII]3+. IR spectroelectrochemistry data suggest that [{Ru(tpy)(bpy)}2( μ-adpc)]3+ is delocalized and [{Ru(tpy)(bpy)}2( μ-Cl2adpc)]3+ and [{Ru(tpy)(bpy)}2( μ-Cl4adpc)]3+ are valence-trapped mixed-valence systems. A NIR absorption band that is unique to all [{Ru(tpy)(bpy)}2( μ-L)]3+ complexes is observed; however, its energy and intensity vary depending on the nature of the bridging ligand and, hence, the complexes oxidation-state description.

ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

Disclosed are compounds of Formula (I), and salts thereof, wherein R1, RA2, RA3 and RA4, are defined herein, which have properties for positive allosteric modulation of mGluR-4 receptor sites. Also described are pharmaceutical formulations comprising the compounds of Formula (I) or their salts, and methods of treating Parkinson's disease and related disorders using the same.