57562-58-0

Usage

InChI:InChI=1/C11H10N2/c1-9-11(7-12-8-13-9)10-5-3-2-4-6-10/h2-8H,1H3

Upstream product

• 1439-09-4 5-bromo-4-methylpyrimidine 
• 98-80-6 phenylboronic acid 

Downstream Products

• 114969-81-2 6-Methyl-5-phenyl-pyrimidine-4-carbonitrile 
• 114969-76-5 4-Methyl-5-phenyl-pyrimidine-2-carbonitrile 
• 114969-95-8 4-Methyl-5-phenyl-pyrimidine 3-oxide 
• 114969-52-7 Picric acid; compound with 4-methyl-5-phenyl-pyrimidine 1-oxide 

Relevant academic research and scientific papers

Suzuki-Miyaura and Negishi approaches to a series of forensically relevant pyridines and pyrimidines

A library of 5-aryl-4-methylpyrimidines, phenyl ring-substituted derivatives of 4-benzylpyrimidines, 2,6-benzylpyridines, and 2,6-dibenzyl-4-methylpyridines were prepared. The synthesis of 5-aryl-4-methylpyrimidines was accomplished by Suzuki-Miyaura cross-coupling reaction between arylboronic acids and 5-bromo-4-methylpyrimidine. The 4-benzylpyrimidines and 2,6-benzylpyridines were synthesized by treatment of 4-bromopyrimidine and 2,6-dibromopyridine derivatives with ring-substituted benzylzinc reagents. Georg Thieme Verlag Stuttgart.

REACTION OF BENZYL KETONES WITH NITRILES IN PRESENCE OF POCl3

The reaction of benzyl ketones with nitriles in presence of POCl3 has been examined.It has been found that intermediate N-styrylimidoyl dichlorophosphates formed under reaction conditions undergo further reactions to isoquinoline and pyrimidine derivatives and form the products of fragmentation and condensation.The effect of structure of the substrates on the relative ratios of the products formed has been discussed.