57575-71-0Relevant academic research and scientific papers
Ligand-free copper(0) catalyzed direct C-H arylation of 1,2,4-triazoles and 1,3,4-oxadiazoles with aryl iodides in PEG-400
Tadikonda, Ramu,Nakka, Mangarao,Rayavarapu, Srinuvasarao,Kalidindi, Siva Prasada Kumar,Vidavalur, Siddaiah
, p. 690 - 692 (2015)
A ligand-free copper catalyzed approach has been developed to the synthesis of 3,4,5-triaryl-1,2,4-triazoles and 2,5-diaryl-1,3,4-oxadiazoles by the direct arylation of corresponding 3,4-diaryl-1,2,4-triazoles and 2-aryl-1,3,4-oxadiazoles with aryl iodides using PEG-400 as reaction medium. The procedure is experimentally simple and free from addition of external chelating ligands or co-catalysts.
Method for synthesizing aryl-substituted triazole compound
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Paragraph 0054; 0055; 0056; 0057; 0058; 0059, (2018/05/16)
The invention provides a method for synthesizing an aryl-substituted 1,2-4-triazole compound of formula (I) as shown in the specification. The method comprises the following steps: in an organic solvent, in the presence of an organic copper catalyst, an alkali and a solubilizer, enabling a compound of formula (II) as shown in the specification and a compound of formula (III) as shown in the specification to react in an inert atmosphere, so as to obtain the compound formula (I) as shown in the specification, in the formula, R1, R2 and R3 are respectively and independently H, C1-C6 alkyl, C1-C6alkoxy, halogen or nitryl, and X is halogen. By adopting the method, through appropriate selection/combination of catalysts, alkalis, solubilizers and organic solvents, a target product of high yieldis prepared, and the method has wide application prospects and great industrial values in the field of synthesis of medicine intermediates.
