5759-80-8

Upstream product

• 4270-27-3 6-chlorouracil 
• 100-46-9 benzylamine 

Downstream Products

• 100763-62-0 5-iodo-6-(benzylamino)uracil 
• 28484-80-2 6-benzylamino-5-bromo-1H-pyrimidine-2,4-dione 
• 21708-43-0 10-benzylbenzo[g]pteridine-2,4(3H,10H)-dione 
• 173691-21-9 N₃-(3-bromopropyl)-10-benzylflavin 
• 845667-71-2 C₁₈H₁₂ClN₃O₂ 
• 846028-40-8 10-benzyl-2H,3H,4H,10H-pyrimido[4,5-b] quinoline-2,4-di-one 

Relevant academic research and scientific papers

5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2

Based on previous reports of certain 5-deazaflavin derivatives being capable of activating the tumour suppressor p53 in cancer cells through inhibition of the p53-specific ubiquitin E3 ligase HDM2, we have conducted an structure-activity relationship (SAR) analysis through systematic modification of the 5-deazaflavin template. This analysis shows that HDM2-inhibitory activity depends on a combination of factors. The most active compounds (e.g., 15) contain a trifluoromethyl or chloro substituent at the deazaflavin C9 position and this activity depends to a large extent on the presence of at least one additional halogen or methyl substituent of the phenyl group at N10. Our SAR results, in combination with the HDM2 RING domain receptor recognition model we present, form the basis for the design of drug-like and potent activators of p53 for potential cancer therapy.

Synthesis of substituted uracils by the reactions of halouracils with selenium, sulfur, oxygen and nitrogen nucleophiles under focused microwave irradiation

Under microwave irradiation, the nucleophilic substitution reactions of halouracils with selenium, sulfur, oxygen and nitrogen nucleophiles was complete within several minutes with yields up to 99%. The method using microwave irradiation is superior to th

Protochlorophyllide reductase III: Synthesis of a protochlorophyllide-dihydroflavin complex

A mild and efficient method of linking a dihydroflavin to the C-17 carboxylic acid side chain of protochlorophyllide, without degradation of the sensitive E ring or loss of magnesium, is described. The appended dihydroflavin was shown to quench the fluorescence of protochlorophyllide. In contrast, a dihydronicotinamide moiety was unable to effect fluorescence quenching. The relevance of these findings to a possible mechanism of action of the enzyme protochlorophyllide reductase is discussed.