57591-47-6

Usage

Uses

Used in Pharmaceutical Industry:
3-(2-Aminophenyl)propan-1-ol is used as a precursor for the production of various drugs and pharmaceutical compounds. Its unique structure, containing both amine and alcohol groups, allows it to be a versatile building block in the synthesis of a wide range of medications.
Used in Dye Industry:
3 (2 AMinophenyl)propan 1 ol ( is also used in the synthesis of dyes, where its chemical properties can contribute to the creation of various colorants for different applications.
Used in Organic Synthesis:
3-(2-Aminophenyl)propan-1-ol is used as a building block in organic synthesis, allowing chemists to create a variety of complex organic compounds for various purposes.
Used as a Reagent in Chemical Reactions:
Due to its functional groups, 3-(2-Aminophenyl)propan-1-ol can act as a reagent in various chemical reactions, facilitating the formation of desired products in the synthesis of different organic compounds.
Used in Industrial Chemical Production:
3 (2 AMinophenyl)propan 1 ol ( can also serve as a precursor for the production of various industrial chemicals, contributing to the development of new materials and products in the chemical industry.

Upstream product

• 1466-88-2 2-nitrocinnamaldehyde 
• 39228-29-0 methyl 2-nitrocinnamate 
• 2437-05-0 ethyl 3-(2-nitrophenyl)acrylate 
• 1466-88-2 2-nitrocinnamic aldehyde 
• 615-43-0 2-iodophenylamine 
• 125812-44-4 2-(2-(hydroxymethyl)ethynyl)aniline 
• 1504-65-0 2-nitrocinnamyl alcohol 

Downstream Products

• 146954-30-5 3-(2-azidophenyl)propan-1-ol 
• 949145-96-4 C₂₅H₄₃NO₅Si 
• 949145-97-5 C₂₁H₂₇NO₃ 
• 949145-98-6 N-[2-(3-hydroxypropyl)phenyl]-N-methylcarbamic acid tert-butyl ester 
• 949145-99-7 C₁₉H₂₉NO₅ 
• 949146-00-3 C₂₁H₂₆NO₂I 
• 949146-01-4 N-[2-(3-iodopropyl)phenyl]-N-methylcarbamic acid tert-butyl ester 
• 949146-02-5 C₁₉H₂₈NO₄I 
• 952595-11-8 C₂₉H₃₁NO₂ 
• 952595-55-0 C₂₃H₂₇NO₂ 
• 952595-66-3 C₂₀H₂₉NO₂ 
• 952595-72-1 C₂₄H₂₇NO₄ 
• 949145-71-5 C₂₄H₂₃N 
• 949145-72-6 C₁₈H₁₉N 

Relevant academic research and scientific papers

Bicyclobutane carboxylic amide as a cysteine-directed strained electrophile for selective targeting of proteins

Expanding the repertoire of electrophiles with unique reactivity features would facilitate the development of covalent inhibitors with desirable reactivity profiles. We herein introduce bicyclo[1.1.0]butane (BCB) carboxylic amide as a new class of thiol-reactive electrophiles for selective and irreversible inhibition of targeted proteins. We first streamlined the synthetic routes to generate a variety of BCB amides. The strain-driven nucleophilic addition to BCB amides proceeded chemoselectively with cysteine thiols under neutral aqueous conditions, the rate of which was significantly slower than that of acrylamide. This reactivity profile of BCB amide was successfully exploited to develop covalent ligands targeting Bruton's tyrosine kinase (BTK). By tuning BCB amide reactivity and optimizing its disposition on the ligand, we obtained a selective covalent inhibitor of BTK. The in-gel activitybased protein profiling and mass spectrometry-based chemical proteomics revealed that the selected BCB amide had a higher target selectivity for BTK in human cells than did a Michael acceptor probe. Further chemical proteomic study revealed that BTK probes bearing different classes of electrophiles exhibited distinct off-target profiles. This result suggests that incorporation of BCB amide as a cysteine-directed electrophile could expand the capability to develop covalent inhibitors with the desired proteome reactivity profile.

Substrate selectivity and its mechanistic insight of the photo-responsive non-nucleoside triphosphate for myosin and kinesin

Linear motor proteins including kinesin and myosin are promising biomaterials for developing nano-devices. Photoswitchable substrates of these biomotors can be used to optically regulate the motility of their associated cytoskeletal filaments in in vitro

Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists

Optimization starting with our lead compound 1 (IC50 = 4.9 nM) led to the identification of pyrrolidinyl phenylurea derivatives. Further modification toward improvement of the bioavailability provided (R)-1-(1-((6-fluoronaphthalen-2-yl)methyl)pyrrolidin-3-yl)-3-(2-(2- hydroxyethoxy)phenyl)urea 32 (IC50 = 1.7 nM), a potent and orally active CCR3 antagonist.

A route to 2-substituted tetrahydroquinolines via palladium-catalyzed intramolecular hydroamination of anilino-alkynes

(Chemical Equation Presented) The cyclization of amino-alkynes 1 in which an amino group is attached to the aromatic ring, proceeded smoothly using a catalytic amount of Pd(PPh3)4 and benzoic acid in toluene at 120°C, leading to the

NOVEL 4-(2FUROYL)AMINOPIPERIDINES, INTERMEDIATES IN SYNTHESIZING THE SAME,PROCESS FOR PRODUCING THE SAME AND MEDICINAL USE OF THE SAME

There are provided novel 4-(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is CH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III): wherein a, b and c are each an integer of 0-6; Z is CH2 or NH; W is O or S; T is O or N-R15 wherein R15 is H, a C1-C6 alkyl group, a benzyl group or a phenethyl group; and R1 is H, a C1-C6 alkoxycarbonyl group, a benzyloxycarbonyl group, or the like.The 4-(2-furoyl) aminopiperidine derivatives according to this invention possess opioid μ antagonistic activity and are useful for the treatment or prevention of side effects which are caused by μ receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.