57591-79-4Relevant academic research and scientific papers
The synthesis of Nα-protected amino hydroxamic acids from Nα-protected amino acids employing versatile chlorinating agent CPI-Cl
Vathsala,Srinivasulu,Santhosh,Sureshbabu, Vommina V.
, p. 449 - 457 (2019/03/08)
Racemization free synthesis of Nα-protected amino hydroxamic acids from Nα-protected amino acids employing the versatile chlorinating reagent CPI-Cl has been described in one-pot. The present protocol has shown compability towards urethane protecting groups like Boc, Cbz and Fmoc, and side chain protections of amino acids showed complete tolerance.
Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN)
Shang, Luqing,Wang, Qiang,Fang, Hao,Mu, Jiajia,Wang, Xuejian,Yuan, Yumei,Wang, Binghe,Xu, Wenfang
experimental part, p. 9984 - 9990 (2009/04/06)
Aminopeptidase N (APN) is an essential peptidase involved in the process of tumor invasion and metastasis. Here we describe a novel class of inhibitor with 3-phenylpropane-1,2-diamine as scaffold to APN. Preliminary activity evaluation with enzyme inhibition studies showed that compound 12i exhibited potent and selective inhibitory activity towards APN with the IC50 value 15.5 ± 1.2 μM.
BIARYL COMPOUND AND USE THEREOF
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Page 39-40, (2008/06/13)
The present invention provides a compound having melanocortin receptor agonist activity or antagonist activity, which is a novel biaryl compound represented by the formula (I) : ???wherein ring A and ring B are optionally further substituted 6-membered ar
