57606-15-2

Upstream product

• 1219455-51-2 8-(tert-Butyl-diphenyl-silanyloxy)-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol 
• 127940-24-3 Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-[((3aR,4S,4aR,7aS,8S,8aR)-8-hydroxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-yloxy)-phenoxy-phosphoryloxy]-ethyl ester 
• 119943-93-0 1-O-(tert-butyldiphenylsilyl)-2,3:5,6-di-O-isopropylidene-D-myo-inositol 
• 128110-25-8 (L)-1,2:4,5-di-O-isopropylidene-myo-inositol 
• 496808-46-9 1D-4-O-benzoyl-1-O-(tert-butyldiphenylsilyl)-2,3,5,6-O-tetrakis(methoxymethylene)-myo-inositol 
• 496921-95-0 C₁₆H₂₆O₆C₁₆H₁₈Si 
• 496808-47-0 1D-1-O-(tert-butyldiphenylsilyl)-2,3,5,6-O-tetrakis(methoxymethylene)-myo-inositol 
• 496808-45-8 1D-4-O-benzoyl-1-O-(tert-butyldiphenylsilyl)-myo-inositol 
• 331679-26-6 2,3-O-(D-1,7,7-trimethylbicyclo[2.2.1]hept-6-ylidene)-D-myo-inositol 
• 496808-59-4 Hexadecanoic acid (R)-2-(diisopropylamino-methoxy-phosphanyloxy)-1-hexadecanoyloxymethyl-ethyl ester 
• 2857-97-8 trimethylsilyl bromide 
• 496808-64-1 1D-O-(1,2-di-O-palmitoyl-sn-glycerol-3-O-methylphospho)-2,3,5,6-O-tetrakis(methoxymethylene)-myo-inositol-4-(dibenzyl phosphate) 
• 127940-25-4 Hexadecanoic acid (R)-2-{[(3aR,4R,4aR,7aS,8R,8aR)-8-(diphenoxy-phosphoryloxy)-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-yloxy]-phenoxy-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester 
• 1042289-75-7 rac-1,2-dipalmitoylglycerol 

Relevant academic research and scientific papers

Comprehensive and uniform synthesis of all naturally occurring phosphorylated phosphatidylinositols

Studies of cellular signal transduction mechanisms involving receptor-mediated generation of inositol phosphates and phosphorylated phosphatidylinositols require easy access to these naturally occurring products. Although numerous synthetic methods have been developed during the past decade, most of these methods suffer from excessive length and lack of generality. In this work we describe the comprehensive and uniform synthesis of all naturally occurring phosphatidylinositols such as phosphatidylinositol, phosphatidylinositol 3-phosphate, 4-phosphate, 5-phosphate, 3,4-bisphosphate, 3,5-bisphosphate, 4,5-bisphosphate, and 3,4,5-trisphosphate, featuring both saturated and unsaturated fatty acid chains.

Comparison of cyclic and acyclic phosphites by selective phosphorylation. Synthesis of phosphatidylinositol 4-phosphate

To compare the synthetic utility of cyclic xylylene N,N-diethylphosphoramidite and its acyclic analog, dibenzyl ester, both phosphites derived from them with dipalmitoylglycerol were subjected to the selective phosphorylation at the OH-3 position in 1,2:4

IMPROVED SYNThESES OF INOSITOL PHOSPHOLIPID ANALOGUES

Short and convenient syntheses of PtdIns 4P and PtdIns analogues based on selective phosphorylation of (+)-2,3:5,6-di-O-isopropylidine-myo-inositol are presented.