57616-01-0

Usage

Chemical structure

2-((pyridin-3-yl)Methyl)hydrazine hydrochloride is a hydrazine derivative that contains a nitrogen-nitrogen bond.

Physical form

The compound is typically found in the form of a white or off-white crystalline powder.

Solubility

It is soluble in water.

Use

It is often used as a reagent in chemical synthesis, particularly in the formation of hydrazones and other organic compounds.

Form

The hydrochloride salt form of 2-((pyridin-3-yl)Methyl)hydrazine hydrochloride allows for better solubility and stability in aqueous solutions.

Potential use

This chemical is also a potential building block for the development of pharmaceuticals, due to its ability to interact with biological systems.

Upstream product

• 348628-13-7 N^α-(pyridine-3-ylmethyl)-N^β-Boc hydrazine 
• 392740-65-7 tert-butyl 2-(pyridin-3-ylmethylene)hydrazinecarboxylate 
• 500-22-1 3-pyridinecarboxaldehyde 

Downstream Products

• 1394136-41-4 N-(4-fluorobenzyl)-5-hydroxy-6-oxo-1-(pyridin-3-ylmethyl)-3-(trifluoromethyl)-1,6-dihydropyridazine-4-carboxamide 
• 201530-52-1 3,5-Bis(2-hydroxyphenyl)-1-(pyridin-3-ylmethyl)-1H-[1,2,4]triazole 

Relevant academic research and scientific papers

6H-THIENO[2,3-E][1,2,4]TRIAZOLO[3,4-C][1,2,4]TRIAZEPINE DERIVATIVE

The 6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivatives or salts thereof of the present invention have BRD4 inhibitory activity, and thus, they are useful as medicaments, in particular, as prophylaxis and/or therapeutic agents for diseases associated with BRD4.

Design, synthesis and antiviral activity of novel pyridazines

A series of pyridazines were prepared and evaluated for their anti-HIV activity. The new synthetic route involving a novel rearrangement reaction provided a practical method for the preparation of 5-hydroxypyridazines. The primary bioassay results indicated that most of the pyridazines possess anti-HIV activity. It ought to been mentioned that the rearranged compounds 35 and 39 exhibited relatively higher HIV inhibitory effect. Most of the synthesized compounds were also found to possess good anti-TMV activity, of which compound 9 showed similar in vivo anti-TMV activity to commercial plant virucide Ribavirin. This work provides a new and efficient approach to evolve novel multi-functional antiviral agents by rational integration and optimization of previously reported antiviral agents.