57619-23-5Relevant articles and documents
Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and method of using same
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, (2008/06/13)
There is provided, novel pro-drug forms of pyridinium aldoxime type cholinesterase reactivators, namely, dihydropyridinium aldoximes, having the formula: SPC1 Wherein R represents a member selected from the group consisting of an alkyl (C1 -C4) group, a SPC2 Group, a SPC3 Group, SPC4 Group, and a SPC5 Wherein Z represents a member selected from the group consisting of a --CH2 --CH2 -- group, a --CH2 --O--CH2 -- group, a --CH2 CH2 OCH2 CH2 -- group, and a --CH2 O--CH2 --CH2 --O--CH2 -- group; wherein R1 represents a member selected from the group consisting of a hydrogen atom, a methyl group, an acyl group and a EQU1 group; and wherein X- represents an anion derived from a pharmaceutically acceptable acid addition salt. These compounds are useful in reactivating cholinesterase, inhibited following exposure to and/or ingestion of conventional anti-cholinesterase agents, especially in the brain.