57631-05-7 Usage
Description
1H-Indazole, 3-(trifluoromethyl)is a chemical compound with the molecular formula C8H5F3N2. It is a derivative of indazole, a bicyclic aromatic heterocycle, and is characterized by the presence of a trifluoromethyl group on the 3 position of the indazole ring. 1H-Indazole, 3-(trifluoromethyl)has potential applications in medicinal chemistry due to its structural features, and it may be used as a building block in the synthesis of pharmaceuticals and agrochemicals. Additionally, the trifluoromethyl group can impart unique physicochemical properties to the compound, making it of interest in the development of novel materials and bioactive compounds.
Uses
Used in Medicinal Chemistry:
1H-Indazole, 3-(trifluoromethyl)is used as a building block for the synthesis of pharmaceuticals and agrochemicals due to its unique structural features. The trifluoromethyl group can enhance the compound's physicochemical properties, making it a valuable component in the development of novel therapeutic agents.
Used in the Development of Novel Materials:
1H-Indazole, 3-(trifluoromethyl)is used in the development of novel materials due to the unique properties imparted by the trifluoromethyl group. 1H-Indazole, 3-(trifluoromethyl)can be utilized in the creation of new materials with specific characteristics, such as improved stability or enhanced bioactivity.
Used in Bioactive Compounds:
1H-Indazole, 3-(trifluoromethyl)is used in the development of bioactive compounds, as the trifluoromethyl group can provide unique properties that can enhance the compound's biological activity. This makes it a promising candidate for the creation of new bioactive molecules with potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 57631-05-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,6,3 and 1 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 57631-05:
(7*5)+(6*7)+(5*6)+(4*3)+(3*1)+(2*0)+(1*5)=127
127 % 10 = 7
So 57631-05-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H5F3N2/c9-8(10,11)7-5-3-1-2-4-6(5)12-13-7/h1-4H,(H,12,13)
57631-05-7Relevant articles and documents
A straightforward access to 3-trifluoromethyl-1H-indazoles via (3+2)-cycloaddition of arynes with nitrile imines derived from trifluoroacetonitrile
Kowalczyk, Anna,Utecht-Jarzyńska, Greta,Mlostoń, Grzegorz,Jasiński, Marcin
, (2020/12/15)
In situ generated arynes react with nitrile imines derived from trifluoroacetonitrile at 0 °C in THF solutions yielding 3-trifluoromethyl-1H-indazole derivatives as the only intermolecular products. The reaction corresponds the expected (3 + 2)-cycloaddit
The structure of fluorinated indazoles: The effect of the replacement of a H by a F atom on the supramolecular structure of NH-indazoles
Teichert, Johannes,Oulie, Pascal,Jacob, Kane,Vendier, Laure,Etienne, Michel,Claramunt, Rosa M.,Lopez, Concepcion,Perez Medina, Carlos,Alkorta, Ibon,Elguero, Jose
, p. 936 - 946 (2008/02/12)
The structures of three NH-indazoles (3-methyl, 3-trifluoromethyl and 3-trifluoromethyl-4,5,6,7-tetrafluoroindazoles) have been determined by X-ray crystallography. These three compounds, together with 3-methyl-4,5,6,7- tetrafluoroindazole, whose X-ray st
Synthesis of 1H-indazoles by reductive cyclization of o-nitro-ketoximes
O'Dell, David K.,Nicholas, Kenneth M.
, p. 373 - 382 (2007/10/03)
ortho-Nitro-ketoximes are converted to 1H-indazoles upon reaction with carbon monoxide with [Cp*Fe(CO)2]2 as catalyst.
