57638-03-6

Basic information

• Product Name: 1-hydroxypentane-1,1-bisphosphonate
• Synonyms: 1-hydroxypentane-1,1-bisphosphonate
• CAS NO: 57638-03-6
• Molecular Formula: C5H14 O7 P2
• Molecular Weight: 248.11
• Mol File: 57638-03-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 539.3°C at 760 mmHg
• Flash Point: 280°C
• Appearance: /
• Density: 1.688g/cm³
• Vapor Pressure: 7E-14mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: 1-hydroxypentane-1,1-bisphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-hydroxypentane-1,1-bisphosphonate(57638-03-6)
• EPA Substance Registry System: 1-hydroxypentane-1,1-bisphosphonate(57638-03-6)

Safety Data

• Hazardous Substances Data: 57638-03-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H14O7P2/c1-2-3-4-5(6,13(7,8)9)14(10,11)12/h6H,2-4H2,1H3,(H2,7,8,9)(H2,10,11,12)

Upstream product

• 55339-93-0 Dimethyl-1-oxopentanphosphonat 
• 638-29-9 n-valeryl chloride 
• 109-52-4 valeric acid 

Relevant articles and documents

A practical synthesis of alendronate sodium through counterattack reaction

An efficient synthesis of alendronate sodium, an osteoporosis drug, has been developed through counterattack reaction' involving treatment of the respective acyl phosphonate with (MeO) and TMSBr followed by deblocking with aqueous HCl.

Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: A potential route to chemotherapy

We have investigated the effects in vitro of a series of bisphosphonates on the proliferation of Trypanosoma cruzi, Trypanosoma brucei rhodesiense, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum. The results show that nitrogen-containing bisphosphonates of the type used in bone resorption therapy have significant activity against parasites, with the aromatic species having in some cases nanomolar or low-micromolar IC50 activity values against parasite replication (e.g. o-risedronate, I50 = 220 nM for T. brucei rhodesiense; risedronate, IC50 = 490 nM for T. gondii). In T. cruzi, the nitrogen-containing bisphosphonate risedronate is shown to inhibit sterol biosynthesis at a pre-squalene level, most likely by inhibiting farnesylpyrophosphate synthase. Bisphosphonates therefore appear to have potential in treating parasitic protozoan diseases.

PHOSPHONYLATION BY TETRAPHOSPHORUS HEXOXIDE

The general usefulness of P4O6 as starting material for the preparation of inorganic and organic phosphorus compounds is demonstrated by reactions of P4O6 with nucleophilic and electrophilic compounds.