57642-05-4

Usage

Uses

Used in Pharmaceutical Research:
1-(1H-Indol-3-Yl)-2-Iodo-Ethanone is used as a research compound for its potential anti-cancer properties. It is investigated for its ability to target and inhibit specific cancer cell pathways, thereby exhibiting promise as a therapeutic agent in oncology.
Used in Organic Synthesis:
In the field of organic chemistry, 1-(1H-Indol-3-Yl)-2-Iodo-Ethanone serves as a valuable precursor for the synthesis of other pharmaceutical compounds. Its unique structure allows for the creation of a variety of molecules with potential applications in medicine and other industries.
Used in Chemical Compound Development:
1-(1H-Indol-3-Yl)-2-Iodo-Ethanone is also utilized as a starting material in the development of new chemical compounds. Its versatility and reactivity make it a popular choice for researchers looking to create novel substances with specific properties and potential uses.

Upstream product

• 703-80-0 3-acetylindole 

Downstream Products

• 73053-81-3 pimprinethine 

Relevant academic research and scientific papers

Mild and General Synthesis of Pyrrolo[2,1-a]isoquinolines and Related Polyheterocyclic Frameworks from Pyrrole Precursors Derived from a Mechanochemical Multicomponent Reaction

The combination of a three-component, solvent-free pyrrole synthesis performed under mechanochemical conditions with a TMSOTf-catalyzed oxonium-mediated cyclization gave general access to pyrrolo[2,1-a]isoquinoline derivatives under very mild conditions.

One-pot total synthesis: The first total synthesis of chiral alkaloid pimprinol A and the facile construction of its natural congeners from amino acids

In this work, we accomplished the first total synthesis of chiral alkaloid pimprinol A and the facile construction of its natural congeners: pimprinine, pimprinethine, pimprinaphine, WS-30581A, WS-30581B, laboradorin 1, uguenenazole, balsoxine, texamine in one-pot from commercially available starting materials including amino acids. Further investigating into the mechanism revealed that this improved transformation was achieved by the integration of iodination, Kornblum oxidation, condensation, decarboxylation, annulation, and oxidation reaction sequence.

Logic design and synthesis of quinoxalines via the integration of iodination/oxidation/cyclization sequences from ketones and 1,2-diamines

A novel protocol for the synthesis of quinoxalines has been developed from simple ketones and 1,2-diamines. This process underwent a logic approach to bis-substituted quinoxalines via a consecutive iodination/Kornblum oxidation/cyclization in the presence of I2/CuO/DMSO and to mono-substituted quinoxalines via an iodination/cyclization/aromatization in the presence of I2/CuO/K3PO4·3H 2O.

Direct α-iodination of aryl alkyl ketones by elemental iodine activated by 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)

Selective introduction of an iodine atom at the α-carbonyl position in various aryl alkyl ketones was effectively achieved by reaction of target molecules with elemental iodine in the presence of N-F reagents. The best results were obtained by using 1-chl