57642-07-6

Basic information

• Product Name: 1-(1H-indol-3-yl)-2-methylpropan-1-one
• CAS NO: 57642-07-6
• Molecular Formula: C₁₂H₁₃NO
• Molecular Weight: 187.2377
• Mol File: 57642-07-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 346.5°C at 760 mmHg
• Flash Point: 171.2°C
• Density: 1.122g/cm³
• Vapor Pressure: 5.75E-05mmHg at 25°C
• Refractive Index: 1.609
• CAS DataBase Reference: 1-(1H-indol-3-yl)-2-methylpropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1H-indol-3-yl)-2-methylpropan-1-one(57642-07-6)
• EPA Substance Registry System: 1-(1H-indol-3-yl)-2-methylpropan-1-one(57642-07-6)

Safety Data

• Hazardous Substances Data: 57642-07-6(Hazardous Substances Data)

Usage

General Description

1-(1H-indol-3-yl)-2-methylpropan-1-one is a chemical compound with a molecular formula C12H13NO. It is also known as 3-(1H-indol-3-yl)-2-methylpropan-1-one, and is a derivative of indole. It is commonly used in organic synthesis and as a precursor in the production of various pharmaceuticals and agrochemicals. 1-(1H-indol-3-yl)-2-methylpropan-1-one has also been studied for its potential biological and pharmacological activities, including as an anti-inflammatory and antioxidant agent. Its unique structure, incorporating an indole ring and a ketone group, makes it an important building block for the synthesis of various complex organic molecules.

Upstream product

• 120-72-9 indole 
• 97-72-3 2-Methylpropionic anhydride 

Downstream Products

• 761338-34-5 2-Amino-1-(1-ethyl-1H-indol-3-yl)-2-methyl-propan-1-one 
• 558470-00-1 1-(4-chlorobenzyl)-3-(1-hydroxy-2-methylpropyl)-1H-indole 
• 558469-96-8 3-iso-butyryl-1-(4-chlorobenzyl)-1H-indole 

Relevant articles and documents

An efficient and green method for regio- and chemo-selective Friedel-Crafts acylations using a deep eutectic solvent ([CholineCl][ZnCl2]3)

[CholineCl][ZnCl2]3, a deep eutectic solvent between choline chloride and ZnCl2, has been used as a dual function catalyst and green solvent for the Friedel-Crafts acylation of aromatic compounds instead of using the moisture-sensitive Lewis acids and volatile organic solvents. The reactions are performed with high yields under microwave irradiation with short reaction times for the synthesis of ketones. Interestingly, indole derivatives are regioselectively acylated in the 3-position under mild conditions with high yields without NH protection. Three new ketone products are synthesized. [CholineCl][ZnCl2]3 is easily synthesized from choline chloride and zinc chloride at a low cost, with easy purification and environmentally benign compounds. [CholineCl][ZnCl2]3 can be reused up to five times without loss of catalytic activity, making it ideal in industrial processes.