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• 120-72-9 indole 
• 96-09-3 styrene oxide 

Relevant academic research and scientific papers

N-SUBSTITUTED INDOLES AND USE AS ALLOSTERIC MODULATORS OF CANNABINOID RECEPTORS

Heteroaromatic compounds are provided which are allosteric modulators of the cannabinoid receptors and which are useful for the treatment of glaucoma, pain, neuropathic pain, post-traumatic stress disorder (PTSD), and neurodegenerative diseases such as Hu

MIL-101(Fe) as an active heterogeneous solid acid catalyst for the regioselective ring opening of epoxides by indoles

Ring opening of an epoxide by a nucleophile is considered as one of the viable strategies to prepare biologically active molecules using homogeneous or heterogeneous Lewis acid catalysts. Very often, the ring opening of epoxide was performed with oxygen,

Iron-containing ionic liquid as an efficient and recyclable catalyst for the synthesis of C3-substituted indole derivatives

A facile and efficient protocol for the synthesis of C3-substituted indole derivatives has been developed under mild condition. The iron-containing ionic liquid, 1-(2-hydroxyethyl)-1,4-diazabicyclo[2.2.2] octanylium tetrachloroferrate ([Dabco-C2/sub

Introduction of an effective and economical heterogeneous ruthenium catalyst for regioselective ring-opening of epoxides and the friedel-crafts alkylation reaction of indoles and pyrroles

Background: Metal organic frameworks square measure crystalline materials with fascinating chemical and physical attributes that include metal ions or clusters and multidentate organic particles. MOFs acquire the expected traits to be employed in classical applications similar to heterogeneous catalysis and storage and separation of gases and different Compounds. Post-synthetic modification (PSM) is an associate replacement method to prepare functionalized MOFs. Methods: The IRMOF-3-PI-RuCl3 was prepared by refluxing a combination of IRMOF-3-PI, [H(DMSO)2][RuCl4(DMSO)2] and ethanol. The amount of ruthenium metal in catalyst was found to be 2.35 w% based on ICP analysis. To perform the ring opening reaction, a solution of styrene oxide, indole, pyrole or alcohol nucleophile, in methanol, IRMOF-3-PI-RuCl3 was added. After completion of the reaction, the catalyst was precipitated. Results: A MOF-supported metal catalyst (IRMOF-3-PI-RuCl3) was designed and synthesized by postsynthetic method. The BET surface area of the final catalyst was slightly reduced as determined by N2 sorption experiments. The results showed that the provided catalyst has a high potential for the ring opening of epoxides with alcohols, indoles and pyrroles under gentle conditions. Conclusion: In summary, a simple, rapid, economical and an effective route for the alcoholysis of epoxides and therefore the Friedel-Crafts alkylation of indoles and pyrroles via an basically regioselective ring opening of epoxides with aliphatic and aromatic amines using IRMOF-3-PI-RuCl3 with cage type poriferous structure as heterogeneous catalysts, has been established. This methodology is very regioselective in numerous instances that give the products with high yield for e.g. in aromatic and aliphatic amines. Ease of separation and straightforward workup are among other advantages of this catalyst.

A highly efficient magnetic solid acid nanocatalyst for the synthesis of new bulky heterocyclic compounds

Fe3O4 nanoparticles were prepared and coated with 3-aminopropyltriethoxysilane (APTES). The formed amine-surfaced Fe3O4@APTES NPs were further chemically modified with maleic anhydride (MAH) to generate Fe3O4@APTES·MAH NPs. This catalyst was characterized by FT-IR, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TG), energy dispersive X-ray analyzer (EDAX), vibrating sample magnetometry (VSM) and the dynamic light scattering (DLS) measurement technique. The catalyst showed high thermal stability and good reusability. Some new bulky heterocyclic compounds such as bis(2,4,5-triarylimidazole), bis(1,4-dihydropyridine), bis(1,8-dioxooctahydroxanthene) and bis(1,8-dioxo-decahydroacridine) derivatives were synthesized using 4,4′-(alkylazanediyl)dibenzaldehyde as substrate and Fe3O4@APTES or Fe3O4@APTES·MAH as catalyst. The high purity products were isolated and the catalyst was easily separated with a simple work-up with magnetic field and was recycled several times without noticeable loss of reactivity under the described reaction conditions.

Ultrasound-assisted regioselective ring opening of epoxides with nitrogen heterocycles using pyrrolidonium and imidazolium-based acidic ionic liquids

Imidazolium and N-methyl-2-pyrrolidonium ionic liquids under ultrasound irradiation were developed as a green and expeditious approach for C-alkylation and N-alkylation of the nitrogen heterocycles including indoles and imidazoles with aliphatic and aroma

Regio- and enantioselective Friedel-Crafts reactions of indoles to epoxides catalyzed by graphene oxide: A green approach

Graphene oxide efficiently promotes high regio- and enantioselective ring opening reactions of aromatic epoxides by indoles addition, in solvent- and metal-free conditions. The Friedel-Crafts products were obtained with enantioselectivity up to 99% ee. Th

Magnetic nano Fe3O4 and CuFe2O4 as heterogeneous catalysts: A green method for the stereo- and regioselective reactions of epoxides with indoles/pyrroles

In this paper, we report a new solvent-free catalytic method using the magnetic nano Fe3O4 and CuFe2O4 as competent heterogeneous catalysts for the stereo- and regioselective reactions of epoxides with indoles/p

A facile synthesis of alkylated nitrogen heterocycles catalysed by 3D mesoporous aluminosilicates with cage type pores in aqueous medium

Friedel-Crafts alkylation of nitrogen heterocycles such as indoles and pyrroles with epoxides has been efficiently carried out using cage-type mesoporous aluminosilicates as recyclable catalysts in water under environmentally benign and mild conditions.

An efficient Friedel-Crafts alkylation of nitrogen heterocycles catalyzed by antimony trichloride/montmorillonite K-10

It has been found that SbCl3 supported on montmorillonite K-10 is an efficient and reusable catalyst for Friedel-Crafts alkylation of nitrogen heterocycles such as indoles and pyrroles with epoxides. The reaction gives the corresponding C-alkyl