57644-26-5Relevant academic research and scientific papers
Synthesis and anti-HIV activity of some isatin derivatives
Sridhar,Pandeya,De Clercq
, p. 302 - 305 (2007/10/03)
Isatin / 5-substituted Isatin was reacted with 2-aminothiazole, 2-aminopyridine, 4-methoxyaniline to form Schiff bases and the N-Mannich bases of the above Schiff bases were synthesized by reacting with formaldehyde and piperidine. The chemical structures of the synthesized compounds were confirmed by means of IR, H-NMR data and elemental analysis. Investigation of Anti-HIV activity was done against replication of HIV-1 (III B) and HIV-2 (ROD) in MT-4 cells. Azidothymidine (AZT) was used as the reference standard. The most active compound of the series was 3-(2-thiazolylimino)-5-bromo-1,3-dihydro-indol-2-one (VI) which demonstrated 28% and 10% protection against HIV-1 and HIV-2 respectively.
Synthesis of Spiro-2,4'(1H)-diones
Rajopadhye, Milind,Popp, Frank D.
, p. 93 - 96 (2007/10/02)
The title compounds have been prepared by the cyclocondensation of 3-mercaptopropanoic acid with isatin-3-imines.The 1-benzyl derivatives have been synthesized by simultaneously reacting 1-benzylisatin, substituted anilines and 3-mercaptopropanoic acid.Ma
