57665-04-0Relevant academic research and scientific papers
Clear Ag-Ag bonds in three silver(I) carboxylate complexes with high cytotoxicity properties
Zhu, Hai-Liang,Zhang, Xian-Ming,Liu, Xiu-Ying,Wang, Xian-Jiang,Liu, Gao-Feng,Usman, Anwar,Fun, Hoong-Kun
, p. 1113 - 1116 (2003)
The reaction of Ag2O and carboxylate ligands in ammonium solution results in three coordination polymers, [Ag(fbc)]n 1, [Ag2(cpd)]n 2 and [Ag2(idc)]n 3, where fbcH is 4-fluorobenzoic acid, cpdH2 is cyclopentane-1,1-dicarboxylic acid and idcH2 is iminodiacetic acid. The X-ray crystal structural analysis indicates that compounds 1 and 2 are two-dimensional frameworks and 3 is a three-dimensional framework. All the three complexes show clear Ag-Ag bonds and high cytotoxicity properties to normal cells and carcinoma cells.
Strong silver-silver interactions in three silver(I) carboxylate complexes with high cytotoxicity properties
Liu, Xiu-Ying,Zhu, Hai-Liang
, p. 325 - 332 (2005)
Three carboxylate silver(I) complexes, [Ag(fbc)]n, (1), [Ag2(cpd)]n (2) and [Ag2(idc)]n (3), were prepared and characterized by X-ray single crystal analysis, where fbcH is 4-fluorobenzoic acid, cpdH2 is cyclopentane-1,1- dicarboxylic acid and idcH2 is iminodiacetic acid. The three coordination polymers show clear Ag-Ag bonds in their structures. The Ag-Ag bond length 2.850 ? both in 1 and 2 is much shorter than that (2.89 A) in metal silver, which is the shortest silver-silver interaction reported. The result of cytotoxicity of the three complexes indicates that they have very high crytotoxicity properties to normal cells and carcinoma cells. Copyright
Synthesis, structures and antimicrobial activity of novel NHC?- and Ph3P-Ag(I)-Benzoate derivatives
O'Beirne, Cillian,Alhamad, Nada F.,Ma, Qinxi,Müller-Bunz, Helge,Kavanagh, Kevin,Butler, Geraldine,Zhu, Xiangming,Tacke, Matthias
, p. 294 - 303 (2018/11/10)
The rising threat of Antimicrobial Resistance (AMR) requires a novel approach to the treatment of infectious diseases. Covalently bonded silver, which has known antibacterial and antifungal properties and multiple mechanisms of action, may provide a treatment strategy when used alone or in combination with already known antimicrobial compounds. Here we describe the synthesis of eight novel silver(I) complexes, which were screened for in vitro activity against two pathogenic bacterial strains, Methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli), and against two pathogenic fungal strains, Candida albicans and Candida parapsilosis. Complexes 5–8 were synthesized by reacting triphenylphosphine in relative equivalents with the relevant silver benzoates (1, 2 & 4), whilst complexes 9–12 were synthesized by generation of a free carbene NHC? (1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene) and reacting this with the silver benzoates 1–4, under Schlenk conditions. Complexes 9–12 showed the strongest antimicrobial activity, resulting in 50% inhibition of growth against MRSA and C. parapsilosis at concentrations of 12.5 and 3.25 μg/mL, respectively.
