57684-71-6

Usage

Uses

Used in Pharmaceutical Industry:
3-(Chloromethyl)isoxazole is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to form diverse interactions with biological macromolecules, contributing to the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
3-(Chloromethyl)isoxazole is used as a building block in the synthesis of agrochemicals, such as pesticides and herbicides, due to its potential to enhance the activity and selectivity of these compounds.
Used in Organic Synthesis:
3-(Chloromethyl)isoxazole is used as an important intermediate in organic synthesis, enabling the production of various fine chemicals and specialty materials. Its versatile reactivity and functional group compatibility make it a valuable component in the synthesis of complex organic molecules.

InChI:InChI=1/C4H4ClNO/c5-3-4-1-2-7-6-4/h1-2H,3H2

Upstream product

• 15787-79-8 chloromethyl β-chlorovinyl ketone 
• 89102-73-8 3-hydroxymethyl isoxazole 

Downstream Products

• 55242-83-6 2-(isoxazol-3-yl)acetonitrile 
• 855741-77-4 diethyl-isoxazol-3-ylmethyl-amine 
• 99071-59-7 N-isoxazol-3-ylmethyl-aniline 
• 76632-20-7 3-(bromomethyl)-1,2-oxazole 
• 872788-70-0 3-iodomethyl-isoxazole 
• 131052-58-9 isoxazol-3-ylmethanamine 

Relevant academic research and scientific papers

Chemical synthesis method of 3-isoxazolyl benzyl acetate

The invention discloses a chemical synthesis method of 3-isoxazolyl benzyl acetate. The chemical synthesis method comprises the following steps: S1, carrying out addition reaction through butene nitrile and bromine gas and generating 3-amino-5-methylisoxazole in the presence of a hydroxylamine derivative; S2, preparing 3-amino-5-methylisoxazole into diazonium salt under low temperature under the action of catalysis, carrying out substitution reaction on the diazonium salt in a hydrochloric acid environment, substituting amino and preparing 3,5-dimethylisooxazole, carrying out demethylation andpreparing 3-chloromethylisoxazole; and S3, adding 3-chloromethylisoxazole and cuprous cyanide into an organic solvent which is dimethyl sulfoxide, reacting and preparing 3-isooxazole acetonitrile. According to the chemical synthesis method of 3-isoxazolyl benzyl acetate, the raw materials are products obtained by directly cracking petroleum; production is carried out by five steps of addition, catalysis, substitution, hydrolysis and esterification; the reaction is rapid; when 3-chloromethylisoxazole as an intermediate is prepared, the yield reaches up to 75%; the production yield is ensured.

A 3 - isoxazole acetate acid animal pen fat chemical synthesis method

The invention relates to a chemical synthesis method of 3-isoxazolyl benzyl acetate. According to the invention, chloroacetyl chloride and acetylene are taken as raw materials, the yield of the reaction is increased by addition, condensation, substitution, hydrolysis and esterification steps and an efficient synthesis method is provided for the synthesis of the compound. The synthesis method mainly comprises steps of adding acetylene, chloroacetyl chloride, catalyst aluminum chloride and a solvent tetrahydrofuran into the reaction vessel, reacting, and separating to obtain 1,4-dichloro-3-butenone after the reaction is completed; adding 1,4-dichloro-3-butenone and ammonium sulfate into a methanol or ethanol solvent, controlling the reaction temperature, and reacting to obtain 3-chloromethyl isoxazole; preparing 3-isoxazole acetonitrile; adding 3-isoxazole oxazol-acetonitrile into hydrochloric acid for hydrolyzing to obtain 3-isoxazole acetic acid; adding 3-isoxazole acetic acid and benzyl alcohol into a dichloromethane or trichloromethane solvent, and adding thionyl chloride and a catalyst N, N-dimethyl-formamide for reacting to obtain 3-isoxazolyl benzyl acetate.

Quinazoline derivatives possessing anti-tumor activity

The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumor activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula: STR1 wherein R1 is hydrogen or amino, or alkyl or alkoxy each of up to 6 carbon atoms; or R1 is substituted alkyl or alkoxy each of up to 3 carbon atoms; R2 is hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, halogenoalkyl or cyanoalkyl each of up to 6 carbon atoms; Ar is phenylene or heterocyclene; L is a group of the formula --CO.NH--, --NH.CO--, --CO.NR3 --, --NR3. CO--, --CH=CH--, --CH2 O--, --OCH2, --CH2 S--, --SCH2 --, --CO.CH2 --, --CH2.CO-- or --CO.O--, wherein R3 is alkyl of up to 6 carbon atoms; and Y is aryl or heteroaryl or a hydrogenated derivative thereof: or Y is a group of the formula --A--Y1 in which A is alkylene, cycloalkylene, alkenylene or alkynylene each of up to 6 carbon atoms and Y1 is aryl or heteroaryl or a hydrogenated derivative thereof; or a pharmaceutically-acceptable salt thereof.

Antibacterial monic acid derivatives

A compound of the formula (I) STR1 wherein R is a group STR2 R1 is hydrogen, phenyl, C1-20 alkyl, C2-8 alkenyl or C2-8 alkynyl each of which may optionally be substituted; or C3-7 cycloalkyl, X is a divalent group --Y--C=C--, and Y is oxygen or sulphur, have antibacterial and/or antimycoplasmal activity.