5769-10-8

Basic information

• Product Name: 4β-Phenylcyclohexan-1α-amine
• Synonyms: 4β-Phenylcyclohexan-1α-amine
• CAS NO: 5769-10-8
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.27008
• Mol File: 5769-10-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4β-Phenylcyclohexan-1α-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4β-Phenylcyclohexan-1α-amine(5769-10-8)
• EPA Substance Registry System: 4β-Phenylcyclohexan-1α-amine(5769-10-8)

Safety Data

• Hazardous Substances Data: 5769-10-8(Hazardous Substances Data)

Upstream product

• 494861-72-2 trans-N-benzhydryl-4-phenylcyclohexanamine 
• 4500-20-3 4-phenylcyclohexanone oxime 
• 4894-75-1 1-phenyl-4-cyclohexanone 
• 28151-46-4 trans-N-benzyl-4-phenylcyclohexan-1-amine 
• 376634-09-2 C₁₂H₁₅N₃ 
• 1466-73-5 trans-4-phenylcyclohexanecarboxylic acid 
• 7335-12-8 cis-4-phenylcyclohexanol 
• 376634-08-1 C₁₃H₁₈O₃S 

Downstream Products

• 32273-50-0 <4t-Phenyl-cyclohexylamino>-acetonitril 
• 32273-52-2 3-<4t-Phenyl-cyclohexylamino>-propionitril 
• 5992-24-5 N-<4-Nitro-benzolsulfonyl>-N'-<4t-phenyl-cyclohexyl>-harnstoff 
• 4754-29-4 N-<4-Methyl-benzolsulfonyl>-N'-<4t-phenyl-cyclohexyl>-harnstoff 
• 4795-58-8 N-<4-Chlor-benzolsulfonyl>-N'-<4t-phenyl-cyclohexyl>-harnstoff 
• 5769-11-9 trans-N-Acetyl-4-phenyl-cyclohexylamin 
• 28142-23-6 trans-N-Benzyliden-4-phenyl-cyclohexylamin 
• 28142-27-0 trans-N-(2-Hydroxy-benzyliden)-4-phenyl-cyclohexylamin 
• 28142-19-0 trans-N-(4-Chlor-benzoyl)-4-phenyl-cyclohexylamin 
• 376634-12-7 trans-4-[3-(4-phenylcyclohexylamino)propyl]phenol 
• 26399-87-1 N-methyl-4-phenylcyclohexanamine 

Relevant articles and documents

Application of Transaminases in a Disperse System for the Bioamination of Hydrophobic Substrates

The challenging bioamination of hydrophobic substrates has been attained through the employment of a disperse system consisting of a combination of a low polarity solvent (e. g. isooctane or methyl-tert-butylether), a non-ionic surfactant and a minimal amount of water. In these conditions, amine transaminases (ATA) were shown to efficiently carry out the reductive amination of variously substituted cyclohexanones, providing good conversions often coupled with a superior stereoselectivity if compared with the corresponding chemical reductive amination. An array of synthetically useful 4-substituted aminocyclohexanes was consequentially synthesized through biocatalysis, analyzed and stereochemically characterized. (Figure presented.).

Reductive amination of ketonic compounds catalyzed by Cp*Ir(III) complexes bearing a picolinamidato ligand

Cp*Ir complexes bearing a 2-picolinamide moiety serve as effective catalysts for the direct reductive amination of ketonic compounds to give primary amines under transfer hydrogenation conditions using ammonium formate as both the nitrogen and hydrogen source. The clean and operationally simple transformation proceeds with a substrate to catalyst molar ratio (S/C) of up to 20,000 at relatively low temperature and exhibits excellent chemoselectivity toward primary amines.

2,2,6,6-Tetramethylpiperidin-1-yloxycarbonyl: A Protecting Group for Primary, Secondary, and Heterocyclic Amines

The 2,2,6,6-tetramethylpiperidin-1-yloxycarbonyl (Tempoc) protecting group is readily introduced by the reaction of amines with a new acyl transfer reagent, 4-nitrophenyl (2,2,6,6-tetramethylpiperidin-1-yl) carbonate (NPTC). Tempoc has a reactivity profile that complements the commonly used t-butyloxycarbonyl (Boc) and benzyloxycarbonyl (Cbz) protecting groups. Deprotection can be achieved under mild reductive conditions with in situ generated Cu(I) species or by thermolytic cleavage at 135 °C. Mechanistic studies on the deprotection of Tempoc-indole suggest a combination of ionic and radical fragmentation pathways under thermal conditions.