577-38-8

Basic information

• Product Name: FLAVANOMAREIN
• Synonyms: TRIHYDROXYFLAVANONE;7-O-GLUCOSYL-4',5',8-TRIHYDROXYFLAVANONE;3',4',7,8-TETRAHYDROXYFLAVANONE-7-O-GLUCOSIDE;FLAVANOMAREIN;ISOOKANIN-7-GLUCOSIDE;ISOOKANIN-7-O-GLUCOSIDE;(S)-2-(3,4-dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-2,3-dihydro-8-hydroxy-4H-1-benzopyran-4-one;FLAVANOMAREIN WITH HPLC
• CAS NO: 577-38-8
• Molecular Formula: C21H22O11
• Molecular Weight: 450.39
• EINECS: 209-411-1
• Product Categories: Flavanones;reagent
• Mol File: 577-38-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 243-246°C
• Boiling Point: 818.2±65.0 °C(Predicted)
• Appearance: /
• Density: 1.665±0.06 g/cm3(Predicted)
• PKA: 7.58±0.40(Predicted)
• CAS DataBase Reference: FLAVANOMAREIN(CAS DataBase Reference)
• NIST Chemistry Reference: FLAVANOMAREIN(577-38-8)
• EPA Substance Registry System: FLAVANOMAREIN(577-38-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 577-38-8(Hazardous Substances Data)

Usage

Description

Flavanomarein, also known as isookanin-7-o-glucoside, is a dihydroflavonoid predominantly found in Coreopsis tinctoria Nutt. It is an active ingredient of the herb with a wide range of pharmacological effects, including antioxidative, antidiabetic, antihypertensive, and anti-hyperlipidemic activities. Flavanomarein has been shown to inhibit high glucose-stimulated epithelial-mesenchymal transition in HK-2 cells by targeting spleen tyrosine kinase.

Uses

Used in Pharmaceutical Applications:
Flavanomarein is used as a therapeutic agent for various health conditions due to its multiple pharmacological properties. It exhibits antioxidative, antidiabetic, antihypertensive, and anti-hyperlipidemic activities, making it a promising candidate for the treatment of diabetes, hypertension, and hyperlipidemia.
Used in Diabetic Nephropathy Treatment:
Flavanomarein is used as a protective agent against diabetic nephropathy, a common complication of diabetes that affects the kidneys. Its protective effects are attributed to its ability to inhibit high glucose-stimulated epithelial-mesenchymal transition in HK-2 cells via targeting spleen tyrosine kinase.
Used in Antioxidant Applications:
Flavanomarein is used as an antioxidant, helping to neutralize harmful free radicals in the body and protect cells from oxidative damage. This property makes it a potential candidate for the prevention and treatment of various diseases associated with oxidative stress, such as cardiovascular diseases, neurodegenerative disorders, and cancer.
Used in Antihypertensive Applications:
Flavanomarein is used as an antihypertensive agent, helping to lower blood pressure and reduce the risk of hypertension-related complications. Its antihypertensive effects contribute to its potential use in the management of hypertension and related cardiovascular diseases.
Used in Anti-hyperlipidemic Applications:
Flavanomarein is used as an anti-hyperlipidemic agent, helping to regulate lipid metabolism and reduce the risk of hyperlipidemia. Its ability to modulate lipid levels makes it a potential candidate for the prevention and treatment of hyperlipidemia and related cardiovascular diseases.