5770-23-0

Basic information

• Product Name: 6-amino-1-benzyl-5-nitrosopyrimidine-2,4(1H,3H)-dione
• Synonyms: 6-amino-1-benzyl-5-nitrosopyrimidine-2,4(1H,3H)-dione
• CAS NO: 5770-23-0
• Molecular Formula: C₁₁H₁₀N₄O₃
• Molecular Weight: 246.2221
• Mol File: 5770-23-0.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 474.5°Cat760mmHg
• Flash Point: 240.8°C
• Appearance: /
• Density: 1.323g/cm³
• Vapor Pressure: 3.6E-09mmHg at 25°C
• Refractive Index: 1.669
• CAS DataBase Reference: 6-amino-1-benzyl-5-nitrosopyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-1-benzyl-5-nitrosopyrimidine-2,4(1H,3H)-dione(5770-23-0)
• EPA Substance Registry System: 6-amino-1-benzyl-5-nitrosopyrimidine-2,4(1H,3H)-dione(5770-23-0)

Safety Data

• Hazardous Substances Data: 5770-23-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C22H16N2O4/c1-14(25)27-18-11-9-15(10-12-18)21(26)23-17-6-4-5-16(13-17)22-24-19-7-2-3-8-20(19)28-22/h2-13H,1H3,(H,23,26)

Upstream product

• 41862-11-7 1-benzyl-6-aminouracil 
• 538-32-9 benzylurea 

Downstream Products

• 1415031-03-6 C₁₇H₁₆N₄O₄S 
• 110480-49-4 3-benzyl-8-[2-(4-diphenylmethylpiperazinyl)ethyl]xanthine 
• 110480-59-6 3-Benzyl-8-(2-methoxy-ethyl)-3,7-dihydro-purine-2,6-dione 
• 110480-64-3 3-Benzyl-8-(2-bromo-ethyl)-3,7-dihydro-purine-2,6-dione 
• 200557-29-5 2,2-Dimethyl-propionic acid 3-benzyl-8-cyclopentyl-1-(2-fluoro-propyl)-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-ylmethyl ester 
• 200557-33-1 2,2-Dimethyl-propionic acid 3-benzyl-8-cyclopentyl-1-(3-hydroxy-propyl)-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-ylmethyl ester 
• 200557-30-8 2,2-Dimethyl-propionic acid 3-benzyl-8-cyclopentyl-1-(3-fluoro-propyl)-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-ylmethyl ester 
• 200557-31-9 2,2-Dimethyl-propionic acid 3-benzyl-8-cyclopentyl-1-(2-hydroxy-ethyl)-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-ylmethyl ester 
• 200557-32-0 2,2-Dimethyl-propionic acid 3-benzyl-8-cyclopentyl-2,6-dioxo-1-(2-oxo-propyl)-1,2,3,6-tetrahydro-purin-7-ylmethyl ester 
• 200556-91-8 3-benzyl-8-cyclopentyl-1H-purine-2,6(3H,7H)-dione 
• 19844-94-1 3-benzyl-6-thioxo-1,3,6,7⁽⁹⁾-tetrahydro-purin-2-one 
• 19844-93-0 3-Benzylxanthine 
• 19844-93-0 3,9-dihydro-3-(phenylmethyl)-1H-purine-2,6-dione 
• 64344-89-4 1-benzyl-6,7-diphenyllumazine 

Relevant articles and documents

Synthesis and Pharmacological Evaluation of Identified and Putative Metabolites of the A1 Adenosine Receptor Antagonist 8-Cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine (CPFPX)

The A1 adenosine receptor (A1AR) antagonist [18F]8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ([18F]CPFPX), used in imaging human brain A1ARs by positron emission tomography (PET), is stable in t

Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from pseudomonas aeruginosa

Glucose-1-phosphate thymidylyltransferase (RmlA) catalyzes the condensation of glucose-1-phosphate (G1P) with deoxy-thymidine triphosphate (dTTP) to yield dTDP-d-glucose and pyrophosphate. This is the first step in the l-rhamnose biosynthetic pathway. l-R

Selective, high affinity A2B adenosine receptor antagonists: N-1 monosubstituted 8-(pyrazol-4-yl)xanthines

A series of N-1 monosubstituted 8-pyrazolyl xanthines have been synthesized and evaluated for their affinity for the adenosine receptors (AdoRs). We have discovered two compounds 18 (CVT-7124) and 28 (CVT-6694) that display good affinity for the A2B AdoR (Ki = 6 nM and 7 nM, respectively) and greater selectivity for the human A1, A2A, and A3 AdoRs (>1000-, >830-, and >1500-fold; >850-, >700-, and >1280-fold, respectively). CVT-6694 has been shown to block the release of interleukin-6 and monocyte chemotactic protein-1 from bronchial smooth muscle cells (BSMC), a process believed to be promoted by activation of A2B AdoR.