5770-40-1

Basic information

• Product Name: 1,3-Dibutyl-pyriMidine-2,4,6-trione
• Synonyms: 1,3-Dibutyl-pyriMidine-2,4,6-trione;1,3-DibutylpyriMidine-2,4,6(1H,3H,5H)-trione;2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dibutyl-
• CAS NO: 5770-40-1
• Molecular Formula: C₁₂H₂₀N₂O₃
• Molecular Weight: 240.2988
• Mol File: 5770-40-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 49-50 °C
• Boiling Point: 328.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.096±0.06 g/cm3(Predicted)
• PKA: 6.24±0.40(Predicted)
• CAS DataBase Reference: 1,3-Dibutyl-pyriMidine-2,4,6-trione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dibutyl-pyriMidine-2,4,6-trione(5770-40-1)
• EPA Substance Registry System: 1,3-Dibutyl-pyriMidine-2,4,6-trione(5770-40-1)

Safety Data

• Hazardous Substances Data: 5770-40-1(Hazardous Substances Data)

Usage

General Description

1,3-Dibutyl-pyrimidine-2,4,6-trione is a chemical compound with the molecular formula C14H21N3O3. It belongs to the pyrimidine-2,4,6-trione group and is derived from pyrimidine. It is a crystalline solid with a pale yellow color and a faint odor. This chemical is used in the pharmaceutical industry as a building block in the synthesis of various drugs and active pharmaceutical ingredients. It also has potential applications in other industries such as agrochemicals and food additives. Additionally, it is important to handle this compound with care due to its potential health hazards and environmental impact.

Upstream product

• 111-36-4 n-butyl isocyanide 
• 161494-64-0 1,3-dibutylpyrimidine-2,4,5,6-tetraone 5-oxime 
• 141-82-2 malonic acid 
• 619-37-4 N,N-di-n-butylurea 
• 1663-67-8 malonoyl dichloride 
• 1792-17-2 N,N'-di-n-butylurea 

Downstream Products

• 1313712-22-9 1,3-dibutyl-5-(1,3-dithian-2-ylidene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1089734-16-6 5-{1-{3,5-bis[(6-(3,3-dimethyl)butyrylamino)pyridin-2-yl]carbamoyl}phenyl-2,6-dimethylpyridin-4-ylidene}-1,3-dibutylpyrimidine-2,4,6-trione 
• 1000063-42-2 5-[4-(di(2-(cholesteryloxycarbonyl)ethyl)amino)benzylidene]-1,3-dibutylpyrimidine-2,4,6-trione 
• 99108-12-0 5-Aminomethylen-1,3-dibutylbarbitursaeure 

Relevant articles and documents

Pyrazolopyrimidine-2,4-dione sulfonamides: Novel and selective calcitonin inducers

A series of pyrazolo[4,3-d]pyrimidine sulfonamides and pyrazolo[3,4-d]pyrimidine sulfonamides have been synthesized. These compounds increase transcription of a calcitonin - luciferase promoter and production of cellular calcitonin in a calcitonin - secre

Malonic Acid Derivatives on Duty as Electron-Withdrawing Units in Push–Pull Molecules

Based on the 2-(N-piperidinyl)thiophene central donor, 32 model push–pull molecules with systematically varied malonic acid-derived peripheral acceptors have been prepared. Further property tuning has been achieved by modifying the π-linker and the structural arrangement (linear vs. quadrupolar D–π–A systems). Malonic acid derivatives such as cyanoacetic acid, malondinitrile, diethyl malonate, Meldrum′s acid, and N,N′-dibutyl(thio)barbituric acid as well as 1,3-diketo analogues dimedone and indan-1,3-dione were employed as acceptor moieties. Knoevenagel condensation with four thiophene aldehydes afforded the target chromophores in satisfactory yields. The electron-withdrawing abilities of malonic acid acceptors were examined both by experiment including X-ray analysis, differential scanning calorimetry, electrochemistry, and UV/Vis absorption spectroscopy, and by DFT calculations. Details of the structure–property relationships have been elucidated. According to the increasing electron-withdrawing ability, the widely used malonic acid acceptor units can be ordered: diethyl malonate ≤ cyanoacetic acid malondinitrile Meldrum's acid dimedone ≤ N,N′-dibutylbarbituric acid indan-1,3-dione ≤ N,N′-dibutylthiobarbituric acid.

PROLYL HYDROXYLASE INHIBITORS

The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I), (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.