5770-40-1Relevant articles and documents
Pyrazolopyrimidine-2,4-dione sulfonamides: Novel and selective calcitonin inducers
Gilbert, Adam M.,Caltabiano, Stephen,Koehn, Frank E.,Chen, Zhen-Jia,Francisco, Gerardo D.,Ellingboe, John W.,Kharode, Yogendra,Mangine, AnnaMarie,Francis, Rita,TrailSmith, Mark,Gralnick, David
, p. 2342 - 2345 (2002)
A series of pyrazolo[4,3-d]pyrimidine sulfonamides and pyrazolo[3,4-d]pyrimidine sulfonamides have been synthesized. These compounds increase transcription of a calcitonin - luciferase promoter and production of cellular calcitonin in a calcitonin - secre
Non-Fullerene Small Molecule Acceptors Containing Barbituric Acid End Groups for Use in High-performance OPVs
Choe, Jong-chan,Lee, Tae Ho,Lim, Eunhee
supporting information, p. 20 - 23 (2018/12/11)
We synthesized two new bithiophene-based small molecules, TT-BBAR, and TT-OBAR, having butyl- and octyl-substituted barbituric acid (BAR) groups, respectively, via a well-known synthetic method, the Knoevenagel condensation, in high yield. These small mol
Malonic Acid Derivatives on Duty as Electron-Withdrawing Units in Push–Pull Molecules
Klikar, Milan,Jelínková, Veronika,R??i?ková, Zdeňka,Mikysek, Tomá?,Pytela, Old?ich,Ludwig, Miroslav,Bure?, Filip
supporting information, p. 2764 - 2779 (2017/05/29)
Based on the 2-(N-piperidinyl)thiophene central donor, 32 model push–pull molecules with systematically varied malonic acid-derived peripheral acceptors have been prepared. Further property tuning has been achieved by modifying the π-linker and the structural arrangement (linear vs. quadrupolar D–π–A systems). Malonic acid derivatives such as cyanoacetic acid, malondinitrile, diethyl malonate, Meldrum′s acid, and N,N′-dibutyl(thio)barbituric acid as well as 1,3-diketo analogues dimedone and indan-1,3-dione were employed as acceptor moieties. Knoevenagel condensation with four thiophene aldehydes afforded the target chromophores in satisfactory yields. The electron-withdrawing abilities of malonic acid acceptors were examined both by experiment including X-ray analysis, differential scanning calorimetry, electrochemistry, and UV/Vis absorption spectroscopy, and by DFT calculations. Details of the structure–property relationships have been elucidated. According to the increasing electron-withdrawing ability, the widely used malonic acid acceptor units can be ordered: diethyl malonate ≤ cyanoacetic acid malondinitrile Meldrum's acid dimedone ≤ N,N′-dibutylbarbituric acid indan-1,3-dione ≤ N,N′-dibutylthiobarbituric acid.
N,N′-Dibutylbarbituric acid as an acceptor moiety in push-pull chromophores
Klikar, Milan,Bures, Filip,Pytela, Oldrich,Mikysek, Tomas,Padelkova, Zdenka,Barsella, Alberto,Dorkenoo, Kokou,Achelle, Sylvain
supporting information, p. 4230 - 4240 (2013/12/04)
Twelve novel D-π-A chromophores with the N,N′-dibutylbarbituric acid acceptor, the N,N-dimethylamino donor and a systematically extended π-linker were synthesized. The extent of intramolecular charge-transfer, structure-property relationships and nonlinear optical properties were further investigated by X-ray analysis, electrochemistry, UV/Vis absorption spectra, calculations and EFISH experiments.
PROLYL HYDROXYLASE INHIBITORS
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Page/Page column 100, (2008/06/13)
The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I), (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
PTH AGONISTS
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Page/Page column 12-13, (2010/02/13)
This invention relates to uracil-derived compounds of forumlas(I) and (II) which are agonists of the parathyroid hormone type I receptor (PTH1R) and as such are useful for the treament of osteoporosis.
Photoprotection compositions comprising certain chelating agents
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, (2008/06/13)
The subject invention relates to methods and compositions comprising: a) from about 0.1% to about 5% of a compound having the structure selected from the group consisting of: STR1 wherein each R is independently selected from the group consisting of hydrogen, alkyl, and aryl; each R' is independently selected from the group consisting of hydrogen, alkoxy, and alkyl; Z and Z' are independently selected from the group consisting of NH, O, and CH2 such that when Z or Z' is NH, the other is not O; or a pharmaceutically acceptable salt of any of the aforementioned compounds; and b) a pharmaceutically-acceptable topical carrier.