57700-95-5Relevant academic research and scientific papers
Direct and Selective C-H Carbamoylation of (Hetero)aromatics with TMSOTf-Activated Carbamoyl Chloride
Uehara, Ayaka,Olivero, Sandra,Michelet, Bastien,Martin-Mingot, Agnès,Thibaudeau, Sébastien,Du?ach, Elisabet
supporting information, p. 46 - 49 (2018/11/27)
Exploiting trimethylsilyltrifluoromethanesulfonate as Lewis acid, (hetero)aromatics underwent regioselective and direct carbamoylation. The method is based on the in situ generation of a highly electrophilic carbamoyl triflate active species.
FeCl3 catalyzed amide compound synthesis method
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Paragraph 0080; 0081; 0082; 0083; 0084, (2018/03/28)
The invention relates to an FeCl3 catalyzed amide compound synthesis method. According to the synthesis method, carboxylic acid and N-substituted formamide are employed to synthesize an amide compound under the catalysis of FeCl3. The synthesis method provided by the invention has the characteristics of mild conditions, high reaction efficiency, and wide applicability to substrates of different functional groups. The amide compound efficiently constructed by the invention is an important skeleton of many organic molecules, drugs, proteins and bioactive molecules. The synthesis method provided by the invention provides a widely applicable preparation method for synthesis of the compounds.
