57715-59-0

Upstream product

• 76789-40-7 2-(4-Fluoro-phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid 
• 76789-32-7 6-Amino-5-(4-fluoro-phenylazo)-1,3-dimethyl-1H-pyrimidine-2,4-dione 
• 76789-37-2 2-(4-Fluoro-phenyl)-5,7-dimethyl-2H,5H-pyrimido[4,5-e][1,2,4]triazine-3,6,8-trione 
• 461-89-2 6-azauracil 
• 1765-93-1 4-fluoroboronic acid 

Relevant academic research and scientific papers

A mild and efficient copper-mediated N-arylation of 6-azauracil with corresponding boronic acids and their antibacterial activity

A convenient synthetic strategy is reported for the synthesis of N-arylated 6-azauracil through Chan-Lam cross-coupling. A variety of N-arylated 6-azauracil derivatives were synthesized in moderate to good yields by cross-coupling of 6-azauracil with arylboronic acids in the presence of Cu(OAc)2 and pyridine. However the arylation position is confirmed in the case of 2-(3,5-dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione (3a), by preparing the compound in a traditional method and compared the chemical shift of the NH proton at N-3 position. Further, the synthesized compounds were screened for their antibacterial activity using agar well diffusion method. The results revealed that most of the synthesized moieties possessing promising therapeutic nature.