57715-83-0Relevant academic research and scientific papers
Anticoccidial derivatives of 6-azauracil. 3. Synthesis, high activity, and short plasma half-life of 1-phenyl-6-azauracils containing sulfonamide substituents
Miller,Mylari,Howes Jr.,Figdor,Lynch,Lynch,Koch
, p. 1083 - 1087 (2007/10/02)
A series of 1-phenyl-6-azauracils containing sulfonamide substituents was prepared. In contrast to previous 1-phenyl-6-azauracils, some of these sulfonamides combine high activity against Eimeria tenella infections in chickens with a very rapid rate of clearance from plasma. Most active was 1-[3'-chloro-5'-methyl-4'-(morpholinyl-sulfonyl)phenyl]-6-azauracil, with a minimum effective concentration in feed of about 10 ppm.
