57716-09-3Relevant articles and documents
VEGFR TYROSINE KINASE INHIBITORS
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Page/Page column 32, (2014/12/12)
Novel compounds, their prodrugs, and the pharmaceutically acceptable salts as pharmaceutical compositions containing such compounds useful in treating certain diseases modulated by the inhibition of vascular endothelial growth factors (VEGFs) receptor tyrosine kinases are provided. In particular, compounds and compositions and the methods for the prophylaxis, management and treatment of cancers through the inhibition of VEGF receptor tyrosine kinases are provided.
Anticoccidial derivatives of 6-azauracil. 3. Synthesis, high activity, and short plasma half-life of 1-phenyl-6-azauracils containing sulfonamide substituents
Miller,Mylari,Howes Jr.,Figdor,Lynch,Lynch,Koch
, p. 1083 - 1087 (2007/10/02)
A series of 1-phenyl-6-azauracils containing sulfonamide substituents was prepared. In contrast to previous 1-phenyl-6-azauracils, some of these sulfonamides combine high activity against Eimeria tenella infections in chickens with a very rapid rate of clearance from plasma. Most active was 1-[3'-chloro-5'-methyl-4'-(morpholinyl-sulfonyl)phenyl]-6-azauracil, with a minimum effective concentration in feed of about 10 ppm.