57718-12-4

Basic information

• Product Name: Benzene, (6-iodo-1-hexynyl)-
• CAS NO: 57718-12-4
• Molecular Formula: C12H13I
• Molecular Weight: 284.14
• Mol File: 57718-12-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzene, (6-iodo-1-hexynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (6-iodo-1-hexynyl)-(57718-12-4)
• EPA Substance Registry System: Benzene, (6-iodo-1-hexynyl)-(57718-12-4)

Safety Data

• Hazardous Substances Data: 57718-12-4(Hazardous Substances Data)

Upstream product

• 540803-87-0 6-phenylhex-5-ynoic acid 
• 536-74-3 phenylacetylene 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 628-21-7 1,4-Diiodobutane 
• 4440-01-1 lithium phenylacetylide 
• 126761-10-2 6-phenyl-hex-5-ynoic acid ethyl ester 

Downstream Products

• 593-60-2 Vinyl bromide 
• 57718-21-5 (1-cyclopentylidene-3-butenyl)benzene 
• 1129-65-3 (hex-1-yn-1-yl)benzene 
• 57718-23-7 (Bromo-cyclopentylidene-methyl)-benzene 
• 1398415-95-6 1-(cyclopentylidene(phenyl)methyl)-3,5-dimethoxybenzene 
• 1221406-95-6 (1-cyclopentylideneethane-1,2-diyl)dibenzene 
• 126497-27-6 2-cyclopentylidene-1-phenylacetic acid 
• 126497-25-4 C₁₂H₁₃⁽²⁾H 
• 4410-77-9 benzylidenecyclopentane 
• 77566-34-8 N-chloro N-ethyl phenyl-6 hexyne-5 yl amine 

Relevant articles and documents

Nickel-Catalyzed Formal Aminocarbonylation of Unactivated Alkyl Iodides with Isocyanides

Herein, we disclose a Ni-catalyzed formal aminocarbonylation of primary and secondary unactivated aliphatic iodides with isocyanides to afford alkyl amide, which proceeds via the selective monomigratory insertion of isocyanides with alkyl iodides, subsequent β-hydride elimination, and hydrolysis process. The reaction features wide functional group tolerance under mild conditions. Additionally, the selective, one-pot hydrolysis of reaction mixture under acid conditions allows for expedient synthesis of the corresponding alkyl carboxylic acid.

Switchable Synthetic Strategy toward Trisubstituted and Tetrasubstituted Exocyclic Alkenes

An efficient and facile method for the construction of tri- or tetrasubstituted exocyclic alkenes is achieved via a Cu(I)-catalytic system. This protocol exhibits mild conditions, low-cost catalyst, good functional group tolerance, and good yields. The selectivity toward tri- or tetrasubstituted alkenes can be delicately controlled by adjustment of base and solvent. A preliminary mechanism study manifested that the reaction undergoes a radical process, where B2pin2 plays an indispensable role.

A direct and stereocontrolled route to conjugated enediynes

A unified synthetic route to 3-hex-en-1,5-diynes, a key building block found in many of the enediyne antitumor agents and designed materials, was developed. The method, which relies on a carbenoid coupling-elimination strategy is tolerant of a wide range of functionalities, and was applied to the synthesis of a variety of linear and cyclic enediynes. Reaction parameters can be adjusted to control stereoselectivity of the process, producing linear enediynes from 1:12 to >100:1 E:Z ratio, and in the case of cyclic enediynes, giving the exclusively Z C-9, C-10, or C-11 products. Key features of the process are the ready availability of precursors and the mildness and efficiency of the reaction. Application of the process in the design of materials precursors and preparation of enediyne antitumor agents are presented.