57723-02-1

Basic information

• Product Name: 1-(2-Morpholinoethyl)-3-phenylthiourea
• Synonyms: 1-(2-Morpholinoethyl)-3-phenylthiourea
• CAS NO: 57723-02-1
• Molecular Formula: C₁₃H₁₉N₃OS
• Molecular Weight: 265.38
• Mol File: 57723-02-1.mol

Chemical Properties

• Melting Point: 136 °C
• Boiling Point: 396.8°C at 760 mmHg
• Flash Point: 193.8°C
• Appearance: /
• Density: 1.204g/cm³
• Vapor Pressure: 1.67E-06mmHg at 25°C
• Refractive Index: 1.622
• PKA: 12.65±0.70(Predicted)
• CAS DataBase Reference: 1-(2-Morpholinoethyl)-3-phenylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Morpholinoethyl)-3-phenylthiourea(57723-02-1)
• EPA Substance Registry System: 1-(2-Morpholinoethyl)-3-phenylthiourea(57723-02-1)

Safety Data

• Hazardous Substances Data: 57723-02-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
1-(2-Morpholinoethyl)-3-phenylthiourea is utilized as a research compound for its potential anticonvulsant properties, making it a candidate for the development of treatments for seizure disorders. Its ability to modulate neuronal activity and potentially reduce seizure frequency is of significant interest in the field of neurology.
Used in Antiviral Drug Development:
In the realm of antiviral research, 1-(2-Morpholinoethyl)-3-phenylthiourea is employed as a potential antiviral agent. Its capacity to inhibit viral replication and reduce viral load makes it a promising candidate for the development of new antiviral medications, particularly in the context of emerging viral threats.
Used in Enzyme Inhibition Studies:
As a potential inhibitor of tyrosine phosphatase enzymes, 1-(2-Morpholinoethyl)-3-phenylthiourea is used in biochemical research to understand the role of these enzymes in various cellular processes. Its application in enzyme inhibition studies aids in the discovery of novel therapeutic targets for diseases associated with dysregulated tyrosine phosphatase activity.
Used in Medicinal Chemistry:
1-(2-Morpholinoethyl)-3-phenylthiourea serves as a key intermediate in the synthesis of various pharmaceutical agents. Its unique structural features allow for the development of new drug candidates with improved efficacy and selectivity, contributing to the advancement of medicinal chemistry.

InChI:InChI=1/C13H19N3OS/c18-13(15-12-4-2-1-3-5-12)14-6-7-16-8-10-17-11-9-16/h1-5H,6-11H2,(H2,14,15,18)

Upstream product

• 2038-03-1 4-(2-AMINOETHYL)MORPHOLINE 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 57723-14-5 3-(2-morpholin-4-yl-ethylimino)-4-phenyl-3,4-dihydro-1H-benzo[e][1,3]thiazepin-5-one 

Relevant articles and documents

Hydroamination and Hydrophosphination of Isocyanates/Isothiocyanates under Catalyst-Free Conditions

Symmetrical and unsymmetrical N,N’-disubstituted as well as trisubstituted ureas/thioureas by the hydroamination of isocyanates/isothiocyanates, and various phosphathioureas by the hydrophosphination of isothiocyanates have been synthesized in good to excellent yields under catalyst-free and mild conditions. This protocol is also applicable for the efficient synthesis of chiral ureas and thioureas and common herbicides, such as fenuron and monuron.

A new scavenger resin for amines

Isatoic anhydride (1) can be attached to Merrifield resin by alkylation on its nitrogen. A maximum loading of 3.2 mmol of anhydride/g of 5 was achieved. This resin, due to the highly reactive anhydride moiety, completely removes primary and secondary aliphatic amines from reactions where they are used in excess.