57743-08-5Relevant academic research and scientific papers
Formation, Dealkylation, and Nucleophilic Substitution of Some Mono- and Di-alkoxypyridoazepines
Patel, Dalpat I.,Scriven, Eric F. V.,Smalley, Robert K.,Suschitzky, Hans
, p. 1911 - 1916 (2007/10/02)
The photo-induced ring-expansions of 5-azido-, 8-azido-, 6-azido-8-metoxy, and 8-azido-6-metoxy-quinolines to alkoxypyridoazepines in alcohol-alkoxide-dioxane solution containing 18-crown-6 are reported, although in some instances azepinone and/or azepine ring contraction products are noted.In addition, ring-expansions in the presence of phenoxide ion have been achieved for the first time. 1H N.m.r. spectra indicate that some of the pyrido-azepines and -azepinones are formed as mixtures of the 5H- and 7H-isomers.Dealkylations and nucleophilic substitution of the alkoxypyridoazepines are discussed,the latter in some instances being accompanied by ring-contraction to diaminoquinolines.
