57754-23-1Relevant academic research and scientific papers
Intramolecular cyclization of alicyclic 1,5-di-and 1,3,5-triketones
Akimova,Ivanenko,Vysotskii
, p. 1068 - 1073 (2001)
On a series of 44 alicyclic 1,5-di-and 1,3,5-triketones was studied the influence of various structural factors (size of the 5-7-membered ring, positions of the substituents) on the capability for intramolecular aldol condensation and on its direction. The most prone to this reaction are compounds possessing a 6-membered cycle and a substituent in the β-methylene bridge. The substituent in α-position to one of the carbonyl groups can affect the reaction in two ways depending on the degree of shielding of this position.
