57764-54-2

Usage

InChI:InChI=1/C10H10O5/c1-2-15-10(14)9(13)7-4-3-6(11)5-8(7)12/h3-5,11-12H,2H2,1H3

Upstream product

• 623-49-4 ethyl cyanoformate 
• 108-46-3 recorcinol 
• 64-17-5 ethanol 

Downstream Products

• 5336-27-6 2,4-dihydroxy-α-oxobenzeneacetic acid 
• 35031-32-4 (3,5-Dibromo-2,4-dihydroxy-phenyl)-oxo-acetic acid ethyl ester 
• 112545-82-1 Ethyl (4-Benzyloxy-2-hydroxyphenyl)-2-oxoacetate 
• 112545-83-2 Ethyl 8-Benzyloxy-2,2a-dihydro-1H,8H-azeto<2,1-b><1,3>benzoxazin-1-one-8-carboxylate 
• 112545-85-4 Benzyl 4-Benzyloxycarbonyloxy-2-hydroxybenzoylformate 
• 112545-86-5 Benzyl 8-Benzyloxycarbonyl-2,2a-dihydro-1H,8H-azeto<2,1-b><1,3>benzoxazin-1-one-8-carboxylate 
• 843646-46-8 [4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-phenyl]-oxo-acetic acid ethyl ester 

Relevant academic research and scientific papers

Aryl ketone amide compound, preparation method and application thereof

The invention discloses an aryl ketoamide compound or a pharmaceutically acceptable salt thereof, a preparation method and application thereof, wherein the compound has a structure represented by a general formula I, and in the formula, substituent groups are defined in the specification and claims. According to the invention, the compound provided by the invention can simultaneously inhibit the activity of various kinases, especially KDR, and further cell level detection results find that the compound has a remarkable inhibition effect on VEGF-induced human umbilical vein endothelial cell HUVEC proliferation, and is a small-molecular VEGFR-2 inhibitor with good activity at the enzyme level and the cell level, so that the compound provided by the invention can be developed into a medicinefor preventing and/or treating tumors or cancers.

BENZOFURAN DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS

The invention relates to novel heterocycles of formula (I), processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.