577708-48-6Relevant academic research and scientific papers
Efficient synthesis of 4,5-disubstituted-3-toluenesulfonyl glutarimides. Application to the formal synthesis of mappicine ketone
Wang, Yung-Sheng,Chang, Nein-Chen,Lin, Ching-Han,Tai, Huo-Mu
, p. 431 - 434 (2008)
Various 4,5-disubstituted-3-sulfonyl glutarimides 3 were synthesized from α-sulfonyl acetamide 1 and ethyl α,β-disubstituted acrylate esters 2 via stepwise facile [3+3] annulation in moderate yield. The synthesis of pyridin-2-one 9, a key intermediate for mappicine ketone (4) synthesis, was also reported.
An efficient approach to 3,4-disubstituted pyridin-2-ones. Formal synthesis of mappicine ketone
Lin, Ching H.,Tsai, Min R.,Wang, Yung S.,Chang, Nein C.
, p. 5688 - 5691 (2007/10/03)
Treatment of 3,4-dihydro-3-tosylpyridin-2-one 5 with sodium hydride and then alkyl halides gave various 3,4-disubstituted pyridin-2-ones 6. Formal synthesis of mappicine ketone (1) was also reported.
