57775-10-7

Upstream product

• 19472-74-3 2-(2-bromophenyl)acetonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 212626-88-5 2-(2-bromophenyl)propionaldehyde 
• 337966-00-4 2-(ortho-bromophenyl)-2-methyl-ethylamine 
• 337966-10-6 [2-(2-Bromo-phenyl)-propyl]-[1-phenyl-eth-(E)-ylidene]-amine 
• 212626-99-8 4-(2-bromophenyl)pentanoic acid ethyl ester 
• 212626-94-3 4-(2-bromophenyl)pent-2-enoic acid ethyl ester 
• 1421692-20-7 (S)-2-(2-bromophenyl)propanenitrile 
• 1421691-98-6 N-(2-(2-bromophenyl)prop-1-en-1-ylidene)-1-(tert-butyl)-1,1-dimethylsilanamine 
• 1616923-27-3 5-benzyloxy-2-(1-biphenyl-2-ylethyl)-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid tert-butyl ester 
• 1616923-28-4 5-benzyloxy-2-(1-biphenyl-2-ylethyl)-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid 
• 1616923-29-5 5-benzyloxy-2-(1-biphenyl-2-ylethyl)-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide 
• 1616923-30-8 5-benzyloxy-2-(1-biphenyl-2-ylethyl)-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide 
• 1616923-31-9 9-benzyloxy-6-(1-biphenyl-2-ylethyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 
• 1616921-82-4 6-(1-biphenyl-2-ylethyl)-9-hydroxy-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 

Relevant academic research and scientific papers

Diastereoselective Construction of Eight-Membered Carbocycles through Palladium-Catalyzed C(sp3)-H Functionalization

A palladium-catalyzed cross-coupling reaction of 2-alkylphenyl bromides with biphenylene has been developed. The reactions formed eight-membered carbocycles through C(sp3)-H activation and the formation of two C-C bonds, and the chiral products were obtai

Cyanide-Free and Broadly Applicable Enantioselective Synthetic Platform for Chiral Nitriles through a Biocatalytic Approach

A cyanide-free platform technology for the synthesis of chiral nitriles by biocatalytic enantioselective dehydration of a wide range of aldoximes is reported. The nitriles were obtained with high enantiomeric excess of >90 % ee (and up to 99 % ee) in many cases, and a “privileged substrate structure” with respect to high enantioselectivity was identified. Furthermore, a surprising phenomenon was observed for the enantiospecificity that is usually not observed in enzyme catalysis. Depending on whether the E or Z isomer of the racemic aldoxime substrate was employed, one or the other enantiomer of the corresponding nitrile was formed preferentially with the same enzyme.

Catalytic asymmetric protonation of silyl ketene imines

An efficient catalytic and highly enantioselective protonation of silyl ketene imines is described. The reaction is catalyzed by the chiral phosphoric acids TRIP or STRIP in the presence of a stoichiometric amount of methanol as the proton source and silyl acceptor. A variety of substituted racemic silyl ketene imines have been transformed into highly enantioenriched nitriles.