577771-25-6Relevant academic research and scientific papers
Synthesis and biological evaluation of new β,β′ -disubstituted 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl ethylamido melatoninergic ligands
Tsotinis,Panoussopoulou,Hough,Sugden
, p. 297 - 304 (2003)
Tricyclic analogs of melatonin with alkyl and cycloalkyl moieties in the β position of the ethylamido chain have been prepared and tested for their ability to activate pigment granule aggregation in Xenopus laevis melanophores. The introduction of two methyl groups in the β position of the side-chain of the methoxyl-substituted ligands induces a synergistic effect in agonist potency, which, importantly, is maintained after the methoxyl substituent is removed. The presence of more bulky β-substituents, regardless of the size of the R group, seems to lead to antagonism.
