577775-45-2Relevant academic research and scientific papers
Novel pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of β-1,6-glucan synthesis
Takeshita, Hiroshi,Watanabe, Jun,Kimura, Yoichi,Kawakami, Katsuhiro,Takahashi, Hisashi,Takemura, Makoto,Kitamura, Akihiro,Someya, Kazuhiko,Nakajima, Ryohei
, p. 3893 - 3896 (2010)
Based on the HTS hit compound 1a, an inhibitor of β-1,6-glucan synthesis, we synthesized novel pyridobenzimidazole derivatives and evaluated their antifungal activity. Among the compounds synthesized, we identified the potent compound 15e, which exhibits
Pyrido[1,2-a]benzimidazole-Based Agents Active Against Tuberculosis (TB), Multidrug-Resistant (MDR) TB and Extensively Drug-Resistant (XDR) TB
Pieroni, Marco,Tipparaju, Suresh K.,Lun, Shichun,Song, Yang,Sturm, A. Willem,Bishai, William R.,Kozikowski, Alan P.
experimental part, p. 334 - 342 (2012/01/12)
The struggle against tuberculosis (TB) is still far from over. TB, caused by Mycobacterium tuberculosis, is one of the deadliest infections worldwide. Co-infection with human immunodeficiency virus (HIV) and the emergence of multidrug-resistant tuberculos
IMIDAZO(1,2-a)PYRIDINE DERIVATIVE
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Page 29, (2010/02/09)
A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.
