577775-51-0Relevant academic research and scientific papers
Catalytic Enantioselective Protonation/Nucleophilic Addition of Diazoesters with Chiral Oxazaborolidinium Ion Activated Carboxylic Acids
Kang, Ki-Tae,Kim, Seung Tae,Hwang, Geum-Sook,Ryu, Do Hyun
supporting information, p. 3977 - 3981 (2017/03/27)
A new chiral Br?nsted acid derived from carboxylic acid and a chiral oxazaborolidinium ion (COBI), as an activator, is introduced. This acid was successfully applied as a catalyst for the highly enantioselective protonation/nucleophilic addition of diazoesters with carboxylic acids.
Catalytic asymmetric insertion of diazoesters into Aryl-CHO bonds: Highly enantioselective construction of chiral all-carbon quaternary centers
Gao, Lizhu,Kang, Byung Chul,Ryu, Do Hyun
supporting information, p. 14556 - 14559 (2013/10/22)
This paper describes a catalytic enantioselective route to synthesize functionalized all-carbon quaternary acyclic systems via a boron Lewis acid-promoted formal C-C insertion of diazoesters into aryl-CHO bonds. In the presence of chiral (S)-oxazaborolidinium cation 1d as a catalyst, the reaction proceeded in good yield (up to 83%) with good regioselectivity (up to 88:12) and excellent enantioselectivity (up to 99% ee). The synthetic potential of this method was illustrated by conversion of the products to both α-and β-amino esters.
Improved palladium-catalysed synthesis of α-benzyl-β-keto esters
Bennett, Nicholas J.,Goldby, Anne,Pringle, Rachel
experimental part, p. 1688 - 1690 (2010/08/20)
This paper describes the development of an imporved protocol for the synthesis of α-benzyl-β-keto esters from aryl bromides via Heck reaction. The use of this protocol to synthesise a variety of diverse α-benzyl-β-keto esters for use in the preparation of new pharmaceutical agents is demonstrated. Georg Thieme Verlag Stuttgart New York.
IMIDAZO(1,2-a)PYRIDINE DERIVATIVE
-
Page 37, (2010/02/09)
A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.
