577776-00-2Relevant academic research and scientific papers
Novel pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of β-1,6-glucan synthesis
Takeshita, Hiroshi,Watanabe, Jun,Kimura, Yoichi,Kawakami, Katsuhiro,Takahashi, Hisashi,Takemura, Makoto,Kitamura, Akihiro,Someya, Kazuhiko,Nakajima, Ryohei
scheme or table, p. 3893 - 3896 (2010/09/03)
Based on the HTS hit compound 1a, an inhibitor of β-1,6-glucan synthesis, we synthesized novel pyridobenzimidazole derivatives and evaluated their antifungal activity. Among the compounds synthesized, we identified the potent compound 15e, which exhibits
IMIDAZO(1,2-a)PYRIDINE DERIVATIVE
-
Page 62, (2010/02/09)
A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.
