5778-80-3Relevant academic research and scientific papers
Convenient preparation of tacrine derivatives by the reduction of 9-aminoacridines with nickel-aluminum alloy
Kamata, Kichinosuke,Tominaga, Yoh-Ichi,Tori-I, Akiyoshi,Thiemann, Thies,Takahashi, Kazufumi,Mataka, Shuntaro
, p. 1683 - 1688 (2007/10/03)
9-Amino-1,2,3,4-tetrahydro- and 9-amino-1,2,3,4,5,6,7,8-octahydro-acridine derivatives (2 and 3) were conveniently prepared in the reduction of the corresponding 2-substituted 9-aminoacridines (1a-f) with nickel-aluminum alloy under basic conditions. The reduction is dependent upon the nature of the substituent in the 2-position of the starting 9-aminoacridines.
Synthesis and cholinesterase inhibitory activity of 6-, 7-methoxy- (and hydroxy-) tacrine derivatives
Del Giudice,Borioni,Mustazza,Gatta,Meneguz,Volpe
, p. 693 - 698 (2007/10/03)
Some 6- and 7-methoxy- (and hydroxy-) tacrine derivatives were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities. The most potent analogue in our series was the 9-heptylamino-6
