57781-14-3 Usage
Originator
Topicon,Pierrel,Italy,1983
Uses
Anti-inflammatory (topical).
Manufacturing Process
100 ml of a 70% hydrofluoric acid aqueous solution were cooled to -10°C in a
polyethylene flask equipped with electromagnetic stirrer. 10 g of 2-bromo-6β-
fluoro-17α,21-dihydroxy-9β, 11β-oxido-pregna-1,4-diene-3,20-dione-17,21-
diacetate were added under stirring during 15 minutes. After 0.5 hour the
reaction mixture was precipitated in water and ammonia. The solid was
collected by filtration, washed with water and dried to a constant weight,
giving about 9.5 g of 2-bromo-6β,9α-difluoro-11β,17α,21 -trihydroxypregna-
1,4-diene-3,20-dione-17,21-diacetate.
Check Digit Verification of cas no
The CAS Registry Mumber 57781-14-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,7,8 and 1 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 57781-14:
(7*5)+(6*7)+(5*7)+(4*8)+(3*1)+(2*1)+(1*4)=153
153 % 10 = 3
So 57781-14-3 is a valid CAS Registry Number.
InChI:InChI=1/C25H29BrF2O7/c1-12(29)34-11-21(33)24(35-13(2)30)6-5-14-15-7-18(27)16-8-19(31)17(26)9-23(16,4)25(15,28)20(32)10-22(14,24)3/h8-9,14-15,18,20,32H,5-7,10-11H2,1-4H3/t14-,15-,18+,20-,22-,23-,24-,25-/m0/s1
57781-14-3Relevant academic research and scientific papers
Method for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
-
, (2008/06/13)
Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.
Steroids and process for preparing the same
-
, (2008/06/13)
Novel steroids are described together with processes of making them and pharmaceutical compositions containing them. The steroids have pharmaceutical activity, especially anti-inflammatory activity. They are all 2-Bromo-6β-fluoro-pregna-1,4-diene-3,20-diones.
