577967-70-5

Usage

Uses

Used in Pharmaceutical Industry:
2-chloro-6,8-difluoroquinoline is used as a building block for the synthesis of various drugs and biologically active compounds. Its quinoline structure and halogen substitutions make it a valuable intermediate for the production of antimalarial, antiviral, and antibacterial agents.
Used in Agrochemicals:
2-chloro-6,8-difluoroquinoline has been studied for its potential use in agrochemicals, where it can be used as a building block for the development of new pesticides and other agrochemical products.
Used as a Fluorescent Probe:
2-chloro-6,8-difluoroquinoline has been studied for its potential use as a fluorescent probe for biological applications. Its chemical properties and versatile reactivity make it a valuable compound for research and development in various fields of science and industry.

Upstream product

• 1209780-69-7 6,8-difluoroquinolin-2-ol 
• 367-25-9 2,4-difluorophenylamine 
• 1384289-62-6 (2E)-N-(2,4-difluorophenyl)cinnamamide 
• 1209780-69-7 6,8-difluoroquinolin-2-one 

Relevant academic research and scientific papers

Compound as potassium channel modulator

The invention relates to a compound as a potassium channel modulator, which is a compound of a formula (I) or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof is effective for curing and preventing diseases and symptoms influenced by the activity of potassium ion channels.

Interaction of polyfluorinated 2-chloroquinolines with ammonia

We have studied the interaction of polyfluorinated (in the benzene moiety) 2-chloroquinolines with liquid and aqueous ammonia as an approach to the synthesis of halogen-containing aminoquinolines. 5,7-Difluoro-, 5,6,8-trifluoro-, and 5,7,8-trifluoro-2-chloroquinolines mostly form products of substitution of the Cl atom, whereas 5,7-difluoro-2,6-dichloroquinoline, 5,6,7,8-tetrafluoro-, and 6,7-difluoro-2-chloroquinolines yield products of substitution of an F atom at various positions. The replacement of liquid ammonia with aqueous causes an increase in the proportion of the products of aminodechlorination relative to the products of aminodefluorination. For 2-chloro-6,8-difluoroquinoline this replacement leads to 2-amino-6,8-difluoroquinoline as the main product instead of the 8-amino-derivative. Activation energy values estimated by DFT calculations for the reactions in question agree with the reaction regioselectivity observed experimentally.

IMIDAZO[1,2-a]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS

Compounds of Formula I and II: I II having the chemical names cis-6-fluoro-8-(3-fluoropiperidin-4-yloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline and 6-fluoro-8-(trans-3-fluoropiperidin-4-yloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline, respectively, and enantiomers and pharmaceutically acceptable salts thereof, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 3 and class 5 receptor tyrosine kinases. The compounds of this invention have also been found to be inhibitors of Pim-1.

TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS

Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.