57798-00-2

Basic information

• Product Name: 4-HYDROXY-8-BROMOQUINOLINE
• Synonyms: 8-BROMOQUINOLIN-4-OL;8-BROMO-4-QUINOLINOL;8-BROMO-4-HYDROXYQUINOLINE;4-HYDROXY-8-BROMOQUINOLINE;BUTTPARK 100\01-51;8-BROMOQUINOLINE-4-OL;8-Bromoquinolin-4(1H)-one;4-HYDROXY-8-BROMOQUINOLINE、8-BroMo-4-hydroxyquinoline
• CAS NO: 57798-00-2
• Molecular Formula: C₉H₆BrNO
• Molecular Weight: 224.05
• EINECS: -0
• Mol File: 57798-00-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 370.732 °C at 760 mmHg
• Flash Point: 178.013 °C
• Appearance: /
• Density: 1.705 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.83±0.40(Predicted)
• CAS DataBase Reference: 4-HYDROXY-8-BROMOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-8-BROMOQUINOLINE(57798-00-2)
• EPA Substance Registry System: 4-HYDROXY-8-BROMOQUINOLINE(57798-00-2)

Safety Data

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 57798-00-2(Hazardous Substances Data)

Usage

Chemical Properties

Off-white powder

Upstream product

• 615-36-1 2-bromoaniline 
• 15568-85-1 5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 2033-24-1 cycl-isopropylidene malonate 
• 1391932-43-6 4-(benzyloxy)-8-bromoquinoline 
• 187278-04-2 5-{[(2-bromophenyl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione 

Downstream Products

• 65340-71-8 8-bromo-4-chloroquinoline 
• 1391932-44-7 4-(benzyloxy)quinoline-8-carbaldehyde 
• 1391932-43-6 4-(benzyloxy)-8-bromoquinoline 
• 874831-36-4 C₁₀H₈BrNO 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)

The present invention relates to compounds of formula (I) and salts, stereoisomers, tautomers or N-oxides thereof that are useful as modulators of STING (Stimulator of Interferon Genes). The present invention further relates to the compounds of formula (I) for use as a medicament and to a pharmaceutical composition comprising said compounds.

QUINOLINE DERIVATIVES AS SMO INHIBITORS

Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.

Photoreductive Removal of O-Benzyl Groups from Oxyarene N-Heterocycles Assisted by O-Pyridine-pyridone Tautomerism

Facile photoreductive protocols have been developed to remove benzyl O-protective groups from oxyarene N-heterocycles at positions capable for 2-/4-O-pyridine-2-/4-pyridone tautomerism. Blue light irradiation, a [Ru] or [Ir] photocatalyst, and ascorbic acid in a water-acetonitrile solution debenzylates a variety of aryl N-heterocycles cleanly and selectively. Ascorbic acid has two functions in the reaction. On the one hand, it protonates the N-heterocycles that reduces their reduction potentials notably and on the other hand it acts as a sacrificial reductant. Reduction potentials and free energy barriers calculated at the CPCM-B3LYP/6-31+G? level can predict the reactivities of the studied substrates.