577995-58-5Relevant academic research and scientific papers
Synthesis of substituted imidazolo[1,2-α]piperidinoses and their evaluation as glycosidase inhibitors
Dubost, Estelle,Le Nouen, Didier,Streith, Jacques,Tarnus, Celine,Tschamber, Theophile
, p. 610 - 626 (2007/10/03)
The synthesis of substituted imidazolo[1,2-α]-L-arabino-piperidinoses is reported. The substituents are methyl, phenylmethyl, phenylethyl, cyclohexylethyl, pyridinylethyl, piperidinylethyl, phenylpropyl and hydroxymethyl. All substituents are connected to
Increasing the inhibitory potency of L-arabino-imidazolo-[1,2]-piperidinose towards β-D-glucosidase and β-D-galactosidase
Dubost, Estelle,Tschamber, Théophile,Streith, Jacques
, p. 3667 - 3670 (2007/10/03)
The synthesis of some potent inhibitors of two retaining β-glycosidases was achieved by introducing aglycon-mimics into the imidazole moiety of L-arabino azasugar 1. The strongest inhibition was observed with the phenyl-ethyl substituent at C(2) of 1 agai
